64325-78-6

Basic information

• Product Name: N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine
• Synonyms: 5'-O-(4,4'-DIMETHOXYTRITYL)-N6-BENZOYL-2'-DEOXYADENOSINE;5'-O-DIMETHOXYTRITYL-N-BENZOYL DESOXYADENOSINE;5'-O-DMT-N6-BZ-2'-DEOXYADENOSINE;N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyadenosine;5'-O-Dimethylterephthalate-N-benzoyl-2-deoxyadenosine;N(6)-BENZOYL-5'-O-(4 4'-DIMETHOXYTRITYL&;N(6)-BENZOYL-5'-O-(4,4'-DIMETHOXY TRITYL) -2'-DEOXY ADENOSINE (DMT-DA-BZ);bz-dmt-da
• CAS NO: 64325-78-6
• Molecular Formula: C₃₈H₃₅N₅O₆
• Molecular Weight: 657.71
• EINECS: 264-776-4
• Product Categories: Organics;Biochemistry;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents
• Mol File: 64325-78-6.mol
• Article Data: 14

Chemical Properties

• Melting Point: 94 °C
• Boiling Point: 681.42°C (rough estimate)
• Appearance: WHITE TO WHITE WITH A YELLOW CAST POWDER
• Density: 1.2199 (rough estimate)
• Refractive Index: -10 ° (C=1, MeOH)
• Storage Temp.: −20°C
• PKA: 7.87±0.43(Predicted)
• Water Solubility: 140μg/L at 20℃
• CAS DataBase Reference: N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine(64325-78-6)
• EPA Substance Registry System: N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine(64325-78-6)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• F: 1-3-10
• Hazardous Substances Data: 64325-78-6(Hazardous Substances Data)

Usage

Flammability and Explosibility

Notclassified

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 4546-72-9 N₆-benzoyl-2'-deoxyadenosine 
• 226415-08-3 N-(9-((2R,3S,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 
• 144924-99-2 N-(9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 
• 958-09-8 2'-deoxy-D-adenosine 
• 40615-35-8 4,4'-dimethoxytrityl alcohol 
• 17331-22-5 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyadenosine 
• 64723-02-0 N-benzoyl-3',5'-di-O-benzoyl-2'-deoxyadenosine 
• 98796-53-3 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] 
• 118352-75-3 Triethylammonium 6-N-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 3'-H-phosphonate 
• 119484-01-4 O-2-cyanoethyl 5'-O-dimethoxytrityl-N⁶-benzoyldeoxyadenosin-3'-yl phosphonate 

Downstream Products

• 74405-42-8 Succinic acid mono-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester 
• 93134-36-2 5'-O-(4,4'-dimethoxytrityl)-N⁶-benzoyl-3'-O-levulinoyl-2'-deoxyadenosine 
• 106216-16-4 N⁶-benzoyl-O^5'-(4,4'-dimethoxy-trityl)-2'-deoxy-[3']adenylic acid 
• 98796-53-3 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] 
• 118352-75-3 Triethylammonium 6-N-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 3'-H-phosphonate 
• 262430-01-3 4-oxo-pentanoic acid 5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[{5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yloxy}-(2-cyano-ethoxy)-phosphanyloxymethyl]-tetrahydro-furan-3-yl ester 
• 682338-01-8 N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-[(diisopropylamino)(4-methylthio-1-butyloxy)phosphinyl]-2'-deoxyadenosine 
• 650599-87-4 N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropylamino)[3-(2-pyridyl)-1-propyloxy]phosphinyl-2'-deoxyadenosine 

Relevant articles and documents

BICYCLIC PEPTIDE LIGAND STING CONJUGATES AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Nucleosidyl-O-methylphosphonates: A pool of monomers for modified oligonucleotides

An unique set of 5′-O- and 3′-O-phosphonomethyl derivatives of four natural 2′-deoxyribonucleosides, 1-(2-deoxy-β-D-threo- pentofuranosyl)thymine, 5′-O- and 2′-O-phosphonomethyl derivatives of 1-(3-deoxy-β-D-erythro-pentofuranosyl)thymine, and 1-(3-deoxy-β-D- threo-pentofuranosyl)thymine has been synthesized as a pool of monomers for the synthesis of modified oligonucleotides. The phosphonate moiety was protected with 4-methoxy-1-oxido-2-pyridylmethyl ester group, serving also as an intramolecular catalyst in the coupling step.

Nucleoside recovery in DNA and RNA synthesis

Nucleoside phosphoramidites and H-phosphonate diesters can be converted to nucleosides under mild conditions and in high yields by reaction with polyhydroxy alcohols.