- Synergistic covalent-and-supramolecular polymers connected by [2]pseudorotaxane moieties
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Synergistic covalent-and-supramolecular polymers, in which covalent polymers and supramolecular polymers connect with each other through [2]pseudorotaxane moieties, are designed and synthesized. The unique topological structure effectively enhances the sy
- Liu, Kai,Qi, Yumeng,Wan, Junjun,Wang, Yongming,Yan, Xuzhou,Yu, Chunyang,Zhang, Xinhai,Zhang, Zhaoming,Zhao, Jun
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supporting information
p. 7374 - 7377
(2021/08/03)
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- Protein micro- and nanopatterning using aminosilanes with protein-resistant photolabile protecting groups
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An approach to the integration of nanolithography with synthetic chemical methodology is described, in which near-field optical techniques are used to selectively deprotect films formed by the adsorption of aminosilanes protected by modified 2-nitrophenylethoxycarbonyl (NPEOC) groups. The NPEOC groups are functionalized at the m- or p-position with either a tetraethyleneglycol or a heptaethylene glycol adduct. We describe the synthesis of these bioresistant aminosilanes and the characterization of the resulting photoreactive films. Photodeprotection by exposure to UV light (λ = 325 nm) yielded the amine with high efficiency, at a similar rate for all four adsorbates, and was complete after an exposure of 2.24 J cm-2. Following photodeprotection, derivatization by trifluoroacetic anhydride was carried out with high efficiency. Micropatterned samples, formed using a mask, were derivatized with aldehyde-functionalized polymer nanoparticles and, following derivatization with biotin, were used to form patterns of avidin-coated polymer particles. Fluorescence microscopy and atomic force microscopy data demonstrated that the intact protecting groups conferred excellent resistance to nonspecific adsorption. Nanometer-scale patterns were created using scanning near-field photolithography and were derivatized with biotin. Subsequent conjugation with avidin-functionalized polymer nanoparticles yielded clear fluorescence images that indicated dense attachment to the nanostructures and excellent protein resistance on the surrounding surface. These simple photocleavable protecting group strategies, combined with the use of near-field exposure, offer excellent prospects for the control of surface reactivity at nanometer resolution in biological systems and offer promise for integrating the top-down and bottom-up molecular fabrication paradigms.
- Alang Ahmad, Shahrul A.,Wong, Lu Shin,Ul-Haq, Ehtsham,Hobbs, Jamie K.,Leggett, Graham J.,Micklefield, Jason
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scheme or table
p. 2749 - 2759
(2011/04/23)
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- Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents
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The PU-H58-dimers 13a-15b were efficiently synthesized and their biological properties were evaluated. The copper-catalyzed alkyne azide coupling was effective in simultaneously linking three components via a triazole formation to afford the target dimers
- Sekiguchi, Hironori,Muranaka, Kazuhiro,Osada, Akiko,Ichikawa, Satoshi,Matsuda, Akira
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experimental part
p. 5732 - 5737
(2010/09/11)
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- Effect of crown ether ring size on binding and fluorescence response to saxitoxin in anthracylmethyl monoazacrown ether chemosensors
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Convenient macrocyclization synthetic routes for the preparation of different-sized monoaza anthracylmethyl crown ether chemosensors (15-crown-5, 18-crown-6, 21-crown-7, 24-crown-8, and 27-crown-9) are described. Evaluation of these crowns as chemosensors for saxitoxin revealed that the larger crowns have moderately higher binding constants, with the 27-crown-9 chemosensor having the largest binding constant (2.29 × 105 (mol/L)-1). Fluorescence enhancements of 100% were observed at saxitoxin concentrations of 5 μmol/L, which is close to the detection limit in mouse bioassay.
- Mao, Hua,Thorne, John B.,Pharr, Jennifer S.,Gawley, Robert E.
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p. 1273 - 1279
(2007/10/03)
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- Macrocyclic receptor molecules with a pendant carboxylic acid group for the complexation of urea
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The synthesis of 5,5'-di-tert-butyl-3-(carboxymethyl)biphenyl crown ethers and several lariat ethers with pendant carboxylic acid groups, together with the determinations of the pKa values of these crown ether carboxylic acids, are described.In
- Aarts, Veronika M. L. J.,Grootenhuis, Peter D. J.,Reinhoudt, David N.,Czech, Anna,Czech, Bronislaw P.,Bartsch, Richard A.
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