69502-27-8

Usage

Uses

Used in Chemical Synthesis:
Heptaethylene glycol di(p-toluenesulfonate) is used as a PEG linker for increasing solubility in aqueous media and facilitating nucleophilic substitution reactions. The hydrophilic PEG spacer improves the solubility of molecules in water, while the tosyl group acts as a good leaving group, making it easier for nucleophiles to attack and form new bonds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Heptaethylene glycol di(p-toluenesulfonate) is used as a versatile building block for the synthesis of various drug candidates. The PEG linker can be used to improve the solubility, stability, and bioavailability of drugs, while the tosyl group can be utilized in the synthesis of complex molecular structures.
Used in Bioconjugation:
Heptaethylene glycol di(p-toluenesulfonate) is used as a bioconjugation agent to attach biologically active molecules, such as proteins, peptides, or other biomolecules, to a PEG backbone. The tosyl group's reactivity allows for efficient coupling, while the PEG spacer provides stability and solubility in aqueous environments.
Used in Drug Delivery Systems:
In drug delivery systems, Heptaethylene glycol di(p-toluenesulfonate) is used as a component in the design of targeted drug carriers. The PEG linker can be functionalized with targeting ligands, while the tosyl group can be used to attach drug molecules, enabling the development of targeted therapies with improved efficacy and reduced side effects.

Upstream product

• 5617-32-3 heptaethylene glycol 
• 98-59-9 p-toluenesulfonyl chloride 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 144270-97-3 1,1,1,24,24,24-hexaphenyl-2,5,8,11,14,17,20,23-octaaoxatetracosane 
• 105891-53-0 1-((2-(2-(2-(2-(2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)methyl)benzene 

Downstream Products

• 922527-86-4 N-benzyl monoaza-27-crown-9 
• 1243536-56-2 1,20-diazido-3,6,9,12,15,18-hexaoxaeicosane 
• 136237-09-7 C₃₄H₄₆O₁₂ 

Relevant academic research and scientific papers

Synergistic covalent-and-supramolecular polymers connected by [2]pseudorotaxane moieties

Synergistic covalent-and-supramolecular polymers, in which covalent polymers and supramolecular polymers connect with each other through [2]pseudorotaxane moieties, are designed and synthesized. The unique topological structure effectively enhances the sy

Protein micro- and nanopatterning using aminosilanes with protein-resistant photolabile protecting groups

An approach to the integration of nanolithography with synthetic chemical methodology is described, in which near-field optical techniques are used to selectively deprotect films formed by the adsorption of aminosilanes protected by modified 2-nitrophenylethoxycarbonyl (NPEOC) groups. The NPEOC groups are functionalized at the m- or p-position with either a tetraethyleneglycol or a heptaethylene glycol adduct. We describe the synthesis of these bioresistant aminosilanes and the characterization of the resulting photoreactive films. Photodeprotection by exposure to UV light (λ = 325 nm) yielded the amine with high efficiency, at a similar rate for all four adsorbates, and was complete after an exposure of 2.24 J cm-2. Following photodeprotection, derivatization by trifluoroacetic anhydride was carried out with high efficiency. Micropatterned samples, formed using a mask, were derivatized with aldehyde-functionalized polymer nanoparticles and, following derivatization with biotin, were used to form patterns of avidin-coated polymer particles. Fluorescence microscopy and atomic force microscopy data demonstrated that the intact protecting groups conferred excellent resistance to nonspecific adsorption. Nanometer-scale patterns were created using scanning near-field photolithography and were derivatized with biotin. Subsequent conjugation with avidin-functionalized polymer nanoparticles yielded clear fluorescence images that indicated dense attachment to the nanostructures and excellent protein resistance on the surrounding surface. These simple photocleavable protecting group strategies, combined with the use of near-field exposure, offer excellent prospects for the control of surface reactivity at nanometer resolution in biological systems and offer promise for integrating the top-down and bottom-up molecular fabrication paradigms.

Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents

The PU-H58-dimers 13a-15b were efficiently synthesized and their biological properties were evaluated. The copper-catalyzed alkyne azide coupling was effective in simultaneously linking three components via a triazole formation to afford the target dimers

Effect of crown ether ring size on binding and fluorescence response to saxitoxin in anthracylmethyl monoazacrown ether chemosensors

Convenient macrocyclization synthetic routes for the preparation of different-sized monoaza anthracylmethyl crown ether chemosensors (15-crown-5, 18-crown-6, 21-crown-7, 24-crown-8, and 27-crown-9) are described. Evaluation of these crowns as chemosensors for saxitoxin revealed that the larger crowns have moderately higher binding constants, with the 27-crown-9 chemosensor having the largest binding constant (2.29 × 105 (mol/L)-1). Fluorescence enhancements of 100% were observed at saxitoxin concentrations of 5 μmol/L, which is close to the detection limit in mouse bioassay.

Macrocyclic receptor molecules with a pendant carboxylic acid group for the complexation of urea

The synthesis of 5,5'-di-tert-butyl-3-(carboxymethyl)biphenyl crown ethers and several lariat ethers with pendant carboxylic acid groups, together with the determinations of the pKa values of these crown ether carboxylic acids, are described.In