- Preparation method of 4- polyfluoro methoxy O-phenylenediamine (by machine translation)
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The method disclosed by the invention 4 - is characterized in that the aminophenol, and the alkali :(1) are reacted at a mole ratio of the 1:0.8-1.5, 20-40 °C compound 0.1-24h with the halogen, and, the halogen compound in the solvent to 1:1.0-3.0,20-120 °C, 0.01-20Mpa react with 1-72h. 1-72h the 4 - 1:0.8-30.0 ammonia solution ;(2)4 - or the halogen compound at a mole ratio of the compound of the 1:0.2 - 2.5 amino phenol, 30-80 °C with 0.1-24h;(3)4 - the halogen and the halogen compound in the solvent 0.1-10%, 50-200 °C, 0.01-10Mpa: 4 . (by machine translation)
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Paragraph 0010-0011
(2020/01/03)
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- Novel imidazopyrimidinyl and imidazopyri dinyl derivatives
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Provided herein are compounds of the formula (I): 1 as well as stereoisomers and pharmaceutically acceptable salts thereof. Such compounds are, because of their ability to antagonize CRF, useful in the treatment of a variety of disorders characterized by
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