- On the trade-off between processability and opto-electronic properties of single wall carbon nanotube derivatives in thin film heterojunctions
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A flow functionalization route has been employed to derivatize single wall carbon nanotubes (SWCNTs) by thienylphenyl groups. The SWCNT derivatives in the most soluble fraction have been characterized by thermogravimetric analysis, DLS analysis, DFT calculations, and UV-vis-NIR, microRaman and IR spectroscopies to study the degree of functionalization, the concentration of SWCNTs in solution, the dimension of the aggregates in solutions, the density of defects, and the presence of the thienylphenyl groups. Thin-film heterojunctions made of SWCNT derivatives and poly(3-hexylthiophene) (P3HT) have been prepared by various methods employing the Langmuir-Schaefer technique, spin-coating and thermal annealing processes. By comparing the batch and the flow functionalizations, a trade-off between solubility, processability and the thin-film opto-electronic properties has been found as a result of the degree of functionalization.
- Salice, Patrizio,Sartorio, Camillo,Burlini, Alessandro,Improta, Roberto,Pignataro, Bruno,Menna, Enzo
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- Influence of the donor size in panchromatic D-π-A-π-A dyes bearing 5-phenyl-5H-dibenzo-[b,f]azepine units for dye-sensitized solar cells
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Two D-π-A-π-A organic dyes (YC-1 and YC-2) with 5-phenyl-5H-dibenzo[b,f]azepine derivatives as donor, thiophene as π bridge, and isoindigo and cyanoacrylic acid as acceptors were prepared. YC-1 and YC-2 show a panchromatic absorption between 300 nm and 800 nm both in solution and neat film. The photovoltaic performances of both dyes were evaluated in dye-sensitized solar cells based on iodide/triiodide electrolyte without any co-sensitizer. The YC-1 based device displays better device performance with open-circuit photocurrent density of 12.12 mA cm-2, open-circuit voltage of 0.53 V, and fill factor of 68.9%, corresponding to overall conversion efficiency (η) of 4.38%. The inferior performance of device based on YC-2 (η = 1.46%) is ascribed to short electron lifetime as evidenced from electrochemical impedance spectroscopy measurement. This research provided a potential promising donor unit for organic dyes and revealed the influence of donor size in organic dyes for photovoltaic performances.
- Wang, Yafei,Yang, Chuncheng,Chen, Jue,Qi, Hongrui,Hua, Jianli,Liu, Yu,Baranoff, Etienne,Tan, Hua,Fan, Jiang,Zhu, Weiguo
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Read Online
- Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities
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This study evaluated the potential use of senescence-inducing small molecules in the treatment of melanoma. We screened commercially available small-molecule libraries with high-throughput screening and high-content screening image-based technology. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold-induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogues were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within.
- Oh, Sangmi,Kwon, Do Yoon,Choi, Inhee,Kim, Young Mi,Lee, Ji Young,Ryu, Jiyoung,Jeong, Hangyeol,Kim, Myung Jin,Song, Rita
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p. 563 - 571
(2021/05/06)
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- Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors
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The main protease (Mpro) of SARS-CoV-2 is a validated antiviral drug target. Several Mpro inhibitors have been reported with potent enzymatic inhibition and cellular antiviral activity, including GC376, boceprevir, calpain inhibitors II, and XII, with eac
- Kitamura, Naoya,Sacco, Michael Dominic,Ma, Chunlong,Hu, Yanmei,Townsend, Julia Alma,Meng, Xiangzhi,Zhang, Fushun,Zhang, Xiujun,Ba, Mandy,Szeto, Tommy,Kukuljac, Adis,Marty, Michael Thomas,Schultz, David,Cherry, Sara,Xiang, Yan,Chen, Yu,Wang, Jun
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- COMPOUNDS AND METHODS TO ATTENUATE TUMOR PROGRESSION AND METASTASIS
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This invention relates to certain compounds or pharmaceutically acceptable salts thereof, and for the use of the compounds to treat cancer. In another aspect, the disclosure relates to a pharmaceutical composition comprising a compound of Formula (1), For
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- Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD?Yap Protein-Protein Interaction
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The Hippo pathway coordinates extracellular signals onto the control of tissue homeostasis and organ size. Hippo signaling primarily regulates the ability of Yap1 to bind and co-activate TEA domain (TEAD) transcription factors. Yap1 tightly binds to TEAD4
- Bum-Erdene, Khuchtumur,Zhou, Donghui,Gonzalez-Gutierrez, Giovanni,Ghozayel, Mona K.,Si, Yubing,Xu, David,Shannon, Harlan E.,Bailey, Barbara J.,Corson, Timothy W.,Pollok, Karen E.,Wells, Clark D.,Meroueh, Samy O.
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p. 378 - 13,389
(2019/03/19)
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- Novel substituted benzoyl compound and its pharmaceutically acceptable salt and preparation method and application (by machine translation)
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The invention relates to the general formula I shown novel substituted benzoyl compound and its pharmaceutically acceptable salt and preparation method and application. The invention also provides pharmaceutical compositions containing them, in vitro and in vivo anti-tumor effect results and acute toxicity study, the obtained anti-tumor drug model substituted benzoyl compound, has more excellent anti-tumor activity and safety, can be in the treatment of leukemia, lung cancer, colon cancer, ovarian cancer and renal carcinoma tumor in the application, so that the therapeutic window, so in the medical field as antitumor agents in the very application value. (by machine translation)
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- One-Pot Palladium-Catalyzed Cross-Coupling Treble of Borylation, the Suzuki Reaction and Amination
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A methodology for a sequential palladium-catalyzed cross-coupling procedure consisting of borylation, the Suzuki reaction and amination has been developed for the assembly of molecules with multi-aryl backbones. The linchpin of this development is the meta-terarylphosphine ligand, Cy*Phine, which has been employed as an air- and moisture-stable precatalyst, Pd(Cy*Phine)2Cl2, to improve the efficiency of one-pot borylation–Suzuki reactions. Additionally, the reactivity of the Pd-Cy*Phine system could be tuned to furnish a one-pot, borylation–Suzuki reaction–amination (BSA) cross-coupling treble. The methodology successfully integrated complementary conditions for three distinctly different and modular reactions. Average yields of 74–94% could be achieved for each segment that cumulatively afforded 50–84% yield over the entire three-step sequence in a single pot. (Figure presented.).
- Jong, Howard,Eey, Stanley T.-C.,Lim, Yee Hwee,Pandey, Sangeeta,Iqbal, Nurul Azmah Bte,Yong, Fui Fong,Robins, Edward G.,Johannes, Charles W.
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supporting information
p. 616 - 622
(2017/02/23)
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- Triphenylamine derivatives and the lithium-ion capture of [3.3]cyclophane used in organic dye-sensitized solar cells
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Four novel organic dyes (H-1, H-2, H-3, H-4) containing phenyl-thiophenyl-thiophenyl as a bridge unit were synthesized and effectively used for the fabrication of dye-sensitized solar cells (DSSCs). In both compounds, a triarylamine moiety and cyanoacryli
- Chiu, Yu-Hsiang,Shibahara, Masahiko,Huang, Rui-Yu,Watanabe, Motonori,Wang, Zhong-Sheng,Hsiao, Yu-Jen,Chang, Bo-Fong,Chiang, Ting-Hsuan,Chang, Yuan Jay
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p. 761 - 772
(2016/09/28)
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- Evidence for Interfacial Halogen Bonding
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A homologous series of donor-π-acceptor dyes was synthesized, differing only in the identity of the halogen substituents about the triphenylamine (TPA; donor) portion of each molecule. Each Dye-X (X=F, Cl, Br, and I) was immobilized on a TiO2 surface to investigate how the halogen substituents affect the reaction between the light-induced charge-separated state, TiO2(e-)/Dye-X+, with iodide in solution. Transient absorption spectroscopy showed progressively faster reactivity towards nucleophilic iodide with more polarizable halogen substituents: Dye-F Dye-Cl Dye-Br Dye-I. Given that all other structural and electronic properties for the series are held at parity, with the exception of an increasingly larger electropositive σ-hole on the heavier halogens, the differences in dye regeneration kinetics for Dye-Cl, Dye-Br, and Dye-I are ascribed to the extent of halogen bonding with the nucleophilic solution species.
- Swords, Wesley B.,Simon, Sarah J.C.,Parlane, Fraser G.L.,Dean, Rebecca K.,Kellett, Cameron W.,Hu, Ke,Meyer, Gerald J.,Berlinguette, Curtis P.
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p. 5956 - 5960
(2016/05/19)
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- Room-temperature Cu(ii)-catalyzed aromatic C-H azidation for the synthesis of ortho-azido anilines with excellent regioselectivity
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Cu(ii)-catalyzed aromatic C-H azidation with azido-benziodoxolone under mild conditions has been described. The primary amine exhibits an excellent ortho-directing effect, providing ortho-azidated anilines as the sole products. the Partner Organisations 2014.
- Fan, Yunpeng,Wan, Wen,Ma, Guobin,Gao, Wei,Jiang, Haizhen,Zhu, Shizheng,Hao, Jian
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supporting information
p. 5733 - 5736
(2014/05/20)
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- Design and synthesis of boronic acid inhibitors of endothelial lipase
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Endothelial lipase (EL) and lipoprotein lipase (LPL) are homologous lipases that act on plasma lipoproteins. EL is predominantly a phospholipase and appears to be a key regulator of plasma HDL-C. LPL is mainly a triglyceride lipase regulating (V)LDL levels. The existing biological data indicate that inhibitors selective for EL over LPL should have anti-atherogenic activity, mainly through increasing plasma HDL-C levels. We report here the synthesis of alkyl, aryl, or acyl-substituted phenylboronic acids that inhibit EL. Many of the inhibitors evaluated proved to be nearly equally potent against both EL and LPL, but several exhibited moderate to good selectivity for EL.
- O'Connell, Daniel P.,Leblanc, Daniel F.,Cromley, Debra,Billheimer, Jeffrey,Rader, Daniel J.,Bachovchin, William W.
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p. 1397 - 1401
(2012/03/26)
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- High-performance organic materials for dye-sensitized solar cells: Triarylene-linked dyads with a 4-tert-butylphenylamine donor
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A series of organic dyes were prepared that displayed remarkable solar-to-energy conversion efficiencies in dye-sensitized solar cells (DSSCs). These dyes are composed of a 4-tert-butylphenylamine donor group (D), a cyanoacrylic-acid acceptor group (A), a
- Chang, Yuan Jay,Chou, Po-Ting,Lin, Szu-Yu,Watanabe, Motonori,Liu, Zhi-Qian,Lin, Ju-Ling,Chen, Kew-Yu,Sun, Shih-Sheng,Liu, Ching-Yang,Chow, Tahsin J.
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experimental part
p. 572 - 581
(2012/05/20)
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- Facile syntheses of thiophene-substituted 1,4-diazabutadiene (α-diimine) ligands and their conversion to phosphenium triiodide salts
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Four novel N-aryl-2-thienyl substituted 1,4-diazabutadiene (α-diimine) ligands 5-8 have been prepared by cyanide ion-catalyzed intermolecular coupling of the appropriate aromatic aldimines. A ligand featuring a phenyl spacer moiety between a thiophene car
- Powell, Adam B.,Brown, Jaclyn R.,Vasudevan, Kalyan V.,Cowley, Alan H.
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experimental part
p. 2521 - 2527
(2009/12/02)
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- Tunable electrochemical switches based on ultrathin organic films
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We have performed electroreduction of bisthienyl aminobenzene and thienyl aminobenzene diazonium salts on glassy carbon and polycrystalline gold and generated ultrathin organic films. This method allows covalent bonding between the corresponding aromatic
- Fave, Claire,Leroux, Yann,Trippe, Gaelle,Randriamahazaka, Hyacinte,Noel, Vincent,Lacroix, Jean-Christophe
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p. 1890 - 1891
(2007/10/03)
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- NOVEL HETEROCYCLIC AMIDE DERIVATIVES HAVING DIHYDROOROTATE DEHYDROGENASE INHIBITING ACTIVITY
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Novel heterocyclic amide derivatives having pharmacological effects, that is, compounds represented by the general formula (1) or salts thereof: (1) wherein X1-X2 is S-CH2 or the like; R1 is alkyl or the like; p is 0 to 7; R2 is hydrogen, alkyl, or the like; R3 is hydrogen, alkyl, or the like; Y1-Y2 is CH=CH or the like; R4 is halogeno, alkyl, or the like; q is 0 to 4; and R5 is halogeno, hydrogen, alkyl, or the like.
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Page/Page column 51; 54
(2010/10/20)
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- GLYT2 MODULATORS
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α-, β-, and γ-amino acid derivatives of formula I are disclosed as selective GlyT2 inhibitors for the treatment of central nervous system (CNS) conditions such as muscle spasticity, tinnitus, epilepsy and neuropathic pain. Formula I
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Page/Page column 98-99
(2010/02/11)
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- Generation and reactivity of the 4-aminophenyl cation by photolysis of 4-chloroaniline
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4-Chloroaniline and its N,N-dimethyl derivative are photostable in cyclohexane but undergo efficient photoheterolysis in polar media via the triplet state and give the corresponding triplet phenyl cations. CASSCF and UB3LYP calculations show that the 4-aminophenyl triplet cation has a planar geometry and is stabilized by > 10 kcal mol-1 with respect to the slightly bent singlet. The triplet has a mixed carbene-diradical character at the divalent carbon. This species either adds to the starting substrate forming 5-chloro-2,4′-diaminodiphenyls (via an intermediate cyclohexadienyl cation) or is reduced to the aniline (via the aniline radical cation) in a ratio depending on the hydrogen-donating properties of the solvent. Transients attributable to the triplet aminophenyl cation as well as to the ensuing intermediates are detected. Chemical evidence for the generation of the phenyl cation is given by trapping via electrophilic substitution with benzene, mesitylene, and hexamethylbenzene (in the last case the main product is a 6-aryl-3-methylene-1,4-cyclohexadiene). Relative rates of electrophilic attack to benzene and to some alkenes and five-membered heterocycles are measured and span over a factor of 15 or 30 for the two cations. The triplet cation formed under these conditions is trapped by iodide more efficiently than by the best π nucleophiles, However, in contrast to the singlet cation, it does not form ethers with alcohols, by which it is rather reduced.
- Guizzardi,Mella,Fagnoni,Freccero,Albini
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p. 6353 - 6363
(2007/10/03)
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- Electro-active monomers comprised of aniline-thiophene units
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Provided are novel, electropolymerizable monomers of the formulae:
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