70010-48-9

Usage

Uses

Used in Pharmaceutical Research:
4-Thiophen-2-ylphenylamine is used as a building block for the synthesis of various drugs and biologically active molecules, contributing to the development of new therapeutic agents.
Used in Organic Synthesis:
4-THIOPHEN-2-YLPHENYLAMINE is utilized as an important intermediate in the production of a variety of organic compounds, highlighting its versatility in chemical reactions and the creation of complex molecules.
Used in Antiviral Applications:
4-Thiophen-2-ylphenylamine is studied for its potential antiviral properties, making it a candidate for further research and development in the treatment of viral infections.
Used in Antifungal Applications:
4-THIOPHEN-2-YLPHENYLAMINE is also being investigated for its antifungal properties, which could lead to its use in combating fungal infections.
Used in Anticancer Applications:
Research into the anticancer properties of 4-Thiophen-2-ylphenylamine is ongoing, with the potential for it to be used in the development of cancer treatments.
Used in Coordination Chemistry:
As a ligand, 4-Thiophen-2-ylphenylamine is used in coordination chemistry to form metal complexes, which can have various applications in different fields, including catalysis and materials science.

InChI:InChI=1/C10H9NS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H,11H2

Upstream product

• 188290-36-0 thiophene 
• 106-47-8 4-chloro-aniline 
• 59156-21-7 2-(4-nitrophenyl)thiophene 
• 96-43-5 2-thienyl chloride 
• 54663-78-4 tributyl(thien-2-yl)stannane 
• 106-40-1 4-bromo-aniline 
• 17763-80-3 para-nitrophenyl triflate 
• 6165-68-0 thiophene boronic acid 
• 586-78-7 para-nitrophenyl bromide 

Downstream Products

• 1056474-34-0 4,4,5,5-tetramethyl-2-(4-(thiophen-2-yl)phenyl)-1,3,2-dioxaborolane 
• 72133-72-3 2-iodothiophene 
• 1266346-00-2 2-(1H-indol-3-yl)-2-oxo-N-(4-(thiophen-2-yl)phenyl)acetamide 
• 1197992-32-7 5-{4-[bis(4-bromophenyl)amino]phenyl}thiophene-2-carbaldehyde 
• 1609111-42-3 2-azido-4-(thiophen-2-yl)aniline 

Relevant academic research and scientific papers

On the trade-off between processability and opto-electronic properties of single wall carbon nanotube derivatives in thin film heterojunctions

A flow functionalization route has been employed to derivatize single wall carbon nanotubes (SWCNTs) by thienylphenyl groups. The SWCNT derivatives in the most soluble fraction have been characterized by thermogravimetric analysis, DLS analysis, DFT calculations, and UV-vis-NIR, microRaman and IR spectroscopies to study the degree of functionalization, the concentration of SWCNTs in solution, the dimension of the aggregates in solutions, the density of defects, and the presence of the thienylphenyl groups. Thin-film heterojunctions made of SWCNT derivatives and poly(3-hexylthiophene) (P3HT) have been prepared by various methods employing the Langmuir-Schaefer technique, spin-coating and thermal annealing processes. By comparing the batch and the flow functionalizations, a trade-off between solubility, processability and the thin-film opto-electronic properties has been found as a result of the degree of functionalization.

Influence of the donor size in panchromatic D-π-A-π-A dyes bearing 5-phenyl-5H-dibenzo-[b,f]azepine units for dye-sensitized solar cells

Two D-π-A-π-A organic dyes (YC-1 and YC-2) with 5-phenyl-5H-dibenzo[b,f]azepine derivatives as donor, thiophene as π bridge, and isoindigo and cyanoacrylic acid as acceptors were prepared. YC-1 and YC-2 show a panchromatic absorption between 300 nm and 800 nm both in solution and neat film. The photovoltaic performances of both dyes were evaluated in dye-sensitized solar cells based on iodide/triiodide electrolyte without any co-sensitizer. The YC-1 based device displays better device performance with open-circuit photocurrent density of 12.12 mA cm-2, open-circuit voltage of 0.53 V, and fill factor of 68.9%, corresponding to overall conversion efficiency (η) of 4.38%. The inferior performance of device based on YC-2 (η = 1.46%) is ascribed to short electron lifetime as evidenced from electrochemical impedance spectroscopy measurement. This research provided a potential promising donor unit for organic dyes and revealed the influence of donor size in organic dyes for photovoltaic performances.

Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors

The main protease (Mpro) of SARS-CoV-2 is a validated antiviral drug target. Several Mpro inhibitors have been reported with potent enzymatic inhibition and cellular antiviral activity, including GC376, boceprevir, calpain inhibitors II, and XII, with eac

Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities

This study evaluated the potential use of senescence-inducing small molecules in the treatment of melanoma. We screened commercially available small-molecule libraries with high-throughput screening and high-content screening image-based technology. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold-induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogues were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within.

COMPOUNDS AND METHODS TO ATTENUATE TUMOR PROGRESSION AND METASTASIS

This invention relates to certain compounds or pharmaceutically acceptable salts thereof, and for the use of the compounds to treat cancer. In another aspect, the disclosure relates to a pharmaceutical composition comprising a compound of Formula (1), For

Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD?Yap Protein-Protein Interaction

The Hippo pathway coordinates extracellular signals onto the control of tissue homeostasis and organ size. Hippo signaling primarily regulates the ability of Yap1 to bind and co-activate TEA domain (TEAD) transcription factors. Yap1 tightly binds to TEAD4

Novel substituted benzoyl compound and its pharmaceutically acceptable salt and preparation method and application (by machine translation)

The invention relates to the general formula I shown novel substituted benzoyl compound and its pharmaceutically acceptable salt and preparation method and application. The invention also provides pharmaceutical compositions containing them, in vitro and in vivo anti-tumor effect results and acute toxicity study, the obtained anti-tumor drug model substituted benzoyl compound, has more excellent anti-tumor activity and safety, can be in the treatment of leukemia, lung cancer, colon cancer, ovarian cancer and renal carcinoma tumor in the application, so that the therapeutic window, so in the medical field as antitumor agents in the very application value. (by machine translation)

One-Pot Palladium-Catalyzed Cross-Coupling Treble of Borylation, the Suzuki Reaction and Amination

A methodology for a sequential palladium-catalyzed cross-coupling procedure consisting of borylation, the Suzuki reaction and amination has been developed for the assembly of molecules with multi-aryl backbones. The linchpin of this development is the meta-terarylphosphine ligand, Cy*Phine, which has been employed as an air- and moisture-stable precatalyst, Pd(Cy*Phine)2Cl2, to improve the efficiency of one-pot borylation–Suzuki reactions. Additionally, the reactivity of the Pd-Cy*Phine system could be tuned to furnish a one-pot, borylation–Suzuki reaction–amination (BSA) cross-coupling treble. The methodology successfully integrated complementary conditions for three distinctly different and modular reactions. Average yields of 74–94% could be achieved for each segment that cumulatively afforded 50–84% yield over the entire three-step sequence in a single pot. (Figure presented.).

Triphenylamine derivatives and the lithium-ion capture of [3.3]cyclophane used in organic dye-sensitized solar cells

Four novel organic dyes (H-1, H-2, H-3, H-4) containing phenyl-thiophenyl-thiophenyl as a bridge unit were synthesized and effectively used for the fabrication of dye-sensitized solar cells (DSSCs). In both compounds, a triarylamine moiety and cyanoacryli

Evidence for Interfacial Halogen Bonding

A homologous series of donor-π-acceptor dyes was synthesized, differing only in the identity of the halogen substituents about the triphenylamine (TPA; donor) portion of each molecule. Each Dye-X (X=F, Cl, Br, and I) was immobilized on a TiO2 surface to investigate how the halogen substituents affect the reaction between the light-induced charge-separated state, TiO2(e-)/Dye-X+, with iodide in solution. Transient absorption spectroscopy showed progressively faster reactivity towards nucleophilic iodide with more polarizable halogen substituents: Dye-F Dye-Cl Dye-Br Dye-I. Given that all other structural and electronic properties for the series are held at parity, with the exception of an increasingly larger electropositive σ-hole on the heavier halogens, the differences in dye regeneration kinetics for Dye-Cl, Dye-Br, and Dye-I are ascribed to the extent of halogen bonding with the nucleophilic solution species.