70010-48-9

Basic information

• Product Name: 4-THIOPHEN-2-YLPHENYLAMINE
• Synonyms: 4-(THIOPHEN-2-YL)ANILINE;4-THIOPHEN-2-YLPHENYLAMINE;4-THIOPHEN-2-YL-PHENYLAMINE HYDROCHLORIDE;4-(2-THIENYL)ANILINE;4-(2-THIENYL)ANILINE HYDROCHLORIDE;AKOS BAR-0200;4-(Thien-2-yl)aniline hydrochloride;4-(thiophen-2-yl)aniline hydrochloride
• CAS NO: 70010-48-9
• Molecular Formula: C₁₀H₉NS
• Molecular Weight: 175.25
• Product Categories: Building Blocks;C10 to C20+;Chemical Synthesis;Heterocyclic Building Blocks;Thiophenes
• Mol File: 70010-48-9.mol
• Article Data: 19

Chemical Properties

• Melting Point: 185-187
• Boiling Point: 307 °C at 760 mmHg
• Flash Point: 139.5 °C
• Appearance: /
• Density: 1.196 g/cm³
• Vapor Pressure: 0.000745mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.04±0.10(Predicted)
• CAS DataBase Reference: 4-THIOPHEN-2-YLPHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-THIOPHEN-2-YLPHENYLAMINE(70010-48-9)
• EPA Substance Registry System: 4-THIOPHEN-2-YLPHENYLAMINE(70010-48-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• PackingGroup: III
• Hazardous Substances Data: 70010-48-9(Hazardous Substances Data)

Usage

General Description

4-Thiophen-2-ylphenylamine, also known as 2-Aminobenzothiophene, is a chemical compound with the molecular formula C12H11NS. It is made up of a phenyl group attached to a thiophene ring and an amine group. 4-Thiophen-2-ylphenylamine is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various drugs and biologically active molecules. It has been studied for its potential antiviral, antifungal, and anticancer properties, and is also used as a ligand in coordination chemistry to form metal complexes. 4-Thiophen-2-ylphenylamine is considered to be an important intermediate in the production of various organic compounds and has a range of potential applications in the field of medicinal chemistry.

InChI:InChI=1/C10H9NS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H,11H2

Upstream product

• 188290-36-0 thiophene 
• 106-47-8 4-chloro-aniline 
• 6165-68-0 thiophene boronic acid 
• 106-40-1 4-bromo-aniline 
• 96-43-5 2-thienyl chloride 
• 54663-78-4 tributyl(thien-2-yl)stannane 
• 586-78-7 para-nitrophenyl bromide 
• 59156-21-7 2-(4-nitrophenyl)thiophene 
• 17763-80-3 para-nitrophenyl triflate 

Downstream Products

• 1154410-96-4 N-[phenylmethylidene]-4-(thiophen-2-yl)aniline 
• 1056474-34-0 4,4,5,5-tetramethyl-2-(4-(thiophen-2-yl)phenyl)-1,3,2-dioxaborolane 
• 72133-72-3 2-iodothiophene 
• 1370333-00-8 (E)-3-(4-(5-(4-(bis(4-tert-butylphenyl)amino)phenyl)thiophen-2-yl)phenyl)-2-cyanoacrylic acid 
• 1370333-07-5 4-(5-(4-(bis(4-tert-butylphenyl)amino)phenyl)thiophen-2-yl)benzaldehyde 
• 1370333-06-4 (N,N-di-tert-butylphenyl)-4-(thiophen-2-yl)aniline 
• 1609111-42-3 2-azido-4-(thiophen-2-yl)aniline 
• 1266346-00-2 2-(1H-indol-3-yl)-2-oxo-N-(4-(thiophen-2-yl)phenyl)acetamide 

Relevant articles and documents

On the trade-off between processability and opto-electronic properties of single wall carbon nanotube derivatives in thin film heterojunctions

A flow functionalization route has been employed to derivatize single wall carbon nanotubes (SWCNTs) by thienylphenyl groups. The SWCNT derivatives in the most soluble fraction have been characterized by thermogravimetric analysis, DLS analysis, DFT calculations, and UV-vis-NIR, microRaman and IR spectroscopies to study the degree of functionalization, the concentration of SWCNTs in solution, the dimension of the aggregates in solutions, the density of defects, and the presence of the thienylphenyl groups. Thin-film heterojunctions made of SWCNT derivatives and poly(3-hexylthiophene) (P3HT) have been prepared by various methods employing the Langmuir-Schaefer technique, spin-coating and thermal annealing processes. By comparing the batch and the flow functionalizations, a trade-off between solubility, processability and the thin-film opto-electronic properties has been found as a result of the degree of functionalization.

Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors

The main protease (Mpro) of SARS-CoV-2 is a validated antiviral drug target. Several Mpro inhibitors have been reported with potent enzymatic inhibition and cellular antiviral activity, including GC376, boceprevir, calpain inhibitors II, and XII, with eac

COMPOUNDS AND METHODS TO ATTENUATE TUMOR PROGRESSION AND METASTASIS

This invention relates to certain compounds or pharmaceutically acceptable salts thereof, and for the use of the compounds to treat cancer. In another aspect, the disclosure relates to a pharmaceutical composition comprising a compound of Formula (1), For

Novel substituted benzoyl compound and its pharmaceutically acceptable salt and preparation method and application (by machine translation)

The invention relates to the general formula I shown novel substituted benzoyl compound and its pharmaceutically acceptable salt and preparation method and application. The invention also provides pharmaceutical compositions containing them, in vitro and in vivo anti-tumor effect results and acute toxicity study, the obtained anti-tumor drug model substituted benzoyl compound, has more excellent anti-tumor activity and safety, can be in the treatment of leukemia, lung cancer, colon cancer, ovarian cancer and renal carcinoma tumor in the application, so that the therapeutic window, so in the medical field as antitumor agents in the very application value. (by machine translation)