700368-52-1Relevant articles and documents
Using ionic liquid cosolvents to improve enzymatic synthesis of arylalkyl β-d-glucopyranosides
Yang, Rong-Ling,Li, Ning,Zong, Min-Hua
experimental part, p. 24 - 28 (2012/05/19)
Enzymatic synthesis of various arylalkyl β-d-glucopyranosides catalyzed by prune (Prunus domestica) seed meal via reverse hydrolysis in the mixture of organic solvent, ionic liquid (IL) and phosphate buffer was described. Among four hydrophilic organic solvents tested, ethylene glycol diacetate (EGDA) was found to be the most suitable for enzymatic synthesis of salidroside, a bioactive compound of commercial interest, from d-glucose and tyrosol. The effects of the nature of ionic liquids and their contents on the enzymatic glucosylation were studied. The addition of a suitable amount of ILs including denaturing ones was favorable to shift the reaction equilibrium toward the synthesis, thus improving the yields. Among the examined ILs, the novel IL [BMIm]I proved to be the best. And this IL was applied as the solvent in biocatalysis for the first time. The yields were found to be enhanced between 0.2-fold and 0.5-fold after the addition of 10% (v/v) [BMIm]I. In 10% (v/v) [BMIm]I-containing system, the desired arylalkyl β-d-glucopyranosides were synthesized with 15-28% yields, among which salidroside was obtained with a yield of 22%. .
COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
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Page/Page column 69-70, (2011/05/06)
The present invention encompasses compounds and methods for treating urinary tract infections.
Use of apple seed meal as a new source of β-glucosidase for enzymatic glucosylation of 4-substituted benzyl alcohols and tyrosol in monophasic aqueous-dioxane medium
Tong, Ai Min,Lu, Wen Ya,Xu, Jian He,Lin, Guo Qiang
, p. 2095 - 2097 (2007/10/03)
A facile method for enzymatic glycosylation of 4-substituted benzyl alcohols and tyrosol with glucose in a monophasic aqueous-dioxane medium was reported, using a crude meal of apple seed as a new catalyst. The corresponding β-D-glucosides were synthesized in moderate yields (13.1-23.1%), among which the salidroside was obtained in 15.8% yield.
Effect of p-substitution of aryl α-D-mannosides on inhibiting mannose-sensitive adhesion of Escherichia coli - Syntheses and testing
Lindhorst, Thisbe K.,Koetter, Sven,Kubisch, Jiri,Krallmann-Wenzel, Ulrike,Ehlers, Stefan,Kren, Vladimir
, p. 1669 - 1674 (2007/10/03)
A series of p-substituted aryl α-D-mannosides was synthesized and tested with regard to their inhibitory capacity in the hemagglutination of guinea pig erythrocytes by type 1 fimbriated Escherichia coli. Synthesis of the bivalent, phenyl-linked mannoside cluster 10 was complicated by orthoester formation during the glycosylation reaction. Surprisingly, the inhibitory potency of 10 was lower than that of p-nitrophenyl α-D-mannoside (1) and this is an important finding for the further design of clustered ligands.
