- Fe3O4@SiO2 nanoparticle supported ionic liquid for green synthesis of antibacterially active 1-carbamoyl-1-phenylureas in water
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In the present work, we have designed a novel, heterogeneous and recyclable magnetic Br?nsted acidic ionic liquid based on 5-phenyl-1H-tetrazole. The {Fe3O4@SiO2@CH2)35-phenyl-1H-tetrazole-SO3H/Cl} ([FSTet-SO3H]Cl) was prepared via the immobilization of 5-phenyl-1H-tetrazole-bonded sulfonic acid onto the surface of silica-coated magnetic nanoparticles using 3-chloropropyltriethoxysilane as a linker. The catalyst was characterized by XRD, TEM, FESEM, EDS, TG-DTA, and FT-IR. The ability and high activity of this catalyst were demonstrated in the synthesis of 1-carbamoyl-1-phenylureas with good to excellent yields via a new, simple and one-pot procedure in aqueous media under reflux conditions. This procedure has advantages such as high yields, short reaction times, a simple methodology and work-up process, green reaction conditions, high stability, catalytic activity, and easy preparation, separation and reusability of the catalyst. The synthesis of these compounds was confirmed by FT-IR, 1H NMR, 13C NMR and CHN. In addition, we investigated the biological properties of the 1-carbamoyl-1-phenylureas as newly synthesized compounds. The described catalyst could be easily separated from the reaction mixture by additional magnetic force and reused several times without a remarkable loss of its catalytic activity and any considerable changes in the product yield and the reaction time.
- Nasrollahzadeh, Mahmoud,Issaabadi, Zahra,Sajadi, S. Mohammad
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p. 27631 - 27644
(2018/08/16)
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- Synthesis, characterization and antibacterial activity of new 1,2- and 1,4-bis(n'-substituted thioureido)benzene derivatives
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Synthesis of two series of 1,2- and 1,4-bis(thioureido)benzene derivatives was accomplished by the treatment of corresponding alkanoyl/aroyl chlorides with potassium thiocyanate in dry acetone to afford the respective isothiocyanates as intermediates. The
- Saeed, Aamer,Abbas, Naeem,Ashraf, Zaman,Bolte, Michael
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p. 273 - 278
(2013/12/04)
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- An efficient, facial and green synthesis of substituted thiourea
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A series of novel substituted N,N'-di(arylaminothiocarbonyl)terephthalamide and 1,4-di(aryloylthioureido)benzene were synthesized by the reaction of terephthaloyl dichloride, ammonium thiocyanate and primary amines, 1,4-phenylenediamine and acyl halide derivatives. The reaction has been completed within 0.5 h in solvent-free condition by grinding the mixture of reactants and afforded the substituted thiourea in good yields.
- Pourshamsian, Khalil,Montazeri, Naser,Khameneh, Aylar Shams
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experimental part
p. 837 - 839
(2012/08/07)
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- Phase transfer catalyzed synthesis of arene-bis-aroyl thiourea derivatives
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Reaction of arene diamines with aroyl chloride and ammonium thiocyanate under the condition of solid-liquid phase transfer catalysis using polyethylene-glycol-600 (PEG-600) as the catalyst furnishes arene-bis-aroyl thioureas 3a-I in good to excellent yiel
- Zhang,Wei,Gao
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p. 700 - 702
(2007/10/03)
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