702675-42-1

Basic information

• Product Name: N-(3-(5-Bromo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
• Synonyms: N-(3-(5-Bromo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide;N-[3-[[5-Bromo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide;N-[3-[[5-bromo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
• CAS NO: 702675-42-1
• Molecular Formula: C₂₃H₂₆BrN₇O₂S
• Molecular Weight: 558.45076
• Mol File: 702675-42-1.mol

Chemical Properties

• Appearance: /
• Density: 1.539g/cm³
• Refractive Index: 1.718
• CAS DataBase Reference: N-(3-(5-Bromo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(5-Bromo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide(702675-42-1)
• EPA Substance Registry System: N-(3-(5-Bromo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide(702675-42-1)

Safety Data

• Hazardous Substances Data: 702675-42-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-(3-(5-Bromo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide is used as a potential pharmaceutical agent for [application reason]. Its complex structure and functional groups may contribute to its activity against specific biological targets or diseases, making it a candidate for drug development.
Used in Agrochemical Industry:
In the agrochemical sector, N-(3-(5-Bromo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide is used as a potential agrochemical compound for [application reason]. Its properties might be harnessed to address challenges in agriculture, such as pest control or crop protection.
Used in Materials Science:
N-(3-(5-Bromo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide is utilized in materials science as a component in the development of new materials with [specific properties] for [application reason]. Its unique molecular structure could offer novel properties that are beneficial in creating advanced materials for various applications.

InChI:InChI=1/C23H26BrN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)

Upstream product

• 527-72-0 2-thiophenylcarboxylic acid 
• 702673-71-0 N-(3-((4-((3-aminopropyl)amino)-5-bromo-2-pyrimidinyl)amino)phenyl)-1-pyrrolidinecarboxamide 
• 1046784-89-7 (3-((5-bromo-2-chloropyrimidin-4-yl)amino)propyl)carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

The design, synthesis and structure-activity relationships of a novel series of 2,4-diamino-5-cyclopropyl pyrimidines is described. Starting from BX795, originally reported to be a potent inhibitor of PDK1, we have developed compounds with improved selectivity and drug-like properties. These compounds have been evaluated in a range of cellular and in vivo assays, enabling us to probe the putative role of the TBK1/IKKε pathway in inflammatory diseases.

CHK-, PDK- AND AKT-INHIBITORY PYRIMIDINES, THEIR PRODUCTION AND USE AS PHARMACEUTICAL AGENTS

This invention relates to pyrimidine derivatives of general formula (I) as inhibitors of kinases, their production as well as their use as medications for treating various diseases.