702673-71-0

Basic information

• Product Name: 1-Pyrrolidinecarboxamide, N-[3-[[4-[(3-aminopropyl)amino]-5-bromo-2-pyrimidinyl]amino]phenyl]-
• CAS NO: 702673-71-0
• Molecular Formula: C18H24BrN7O
• Molecular Weight: 434.339
• Mol File: 702673-71-0.mol

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxamide, N-[3-[[4-[(3-aminopropyl)amino]-5-bromo-2-pyrimidinyl]amino]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxamide, N-[3-[[4-[(3-aminopropyl)amino]-5-bromo-2-pyrimidinyl]amino]phenyl]-(702673-71-0)
• EPA Substance Registry System: 1-Pyrrolidinecarboxamide, N-[3-[[4-[(3-aminopropyl)amino]-5-bromo-2-pyrimidinyl]amino]phenyl]-(702673-71-0)

Safety Data

• Hazardous Substances Data: 702673-71-0(Hazardous Substances Data)

Upstream product

• 702638-74-2 pyrrolidine-1-carboxylic acid (3-amino-phenyl)-amide 
• 1046784-89-7 (3-((5-bromo-2-chloropyrimidin-4-yl)amino)propyl)carbamic acid tert-butyl ester 

Downstream Products

• 702675-42-1 N-(3-((5-bromo-4-((3-((2-thienylcarbonyl)amino)propyl)amino)-2-pyrimidinyl)amino)phenyl)-1-pyrrolidinecarboxamide 
• 702672-52-4 [3-[[5-bromo-2-[[3-[(1-pyrrolidinylcarbonyl)amino]phenyl]amino]-4-pyrimidinyl]amino]propyll]-carbamothioic acid S-ethyl ester 
• 702672-50-2 N-[3-[[5-bromo-4-[[3-[[(ethylamino)thioxomethyl]amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide 
• 702672-54-6 N-[3-[[4-[[3-[(aminosulfonyl)amino]propyl]amino]-5-bromo-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide 
• 702672-45-5 N-[3-[[5-bromo-4-[[3-[(propylsulfonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide 
• 702672-47-7 N-[3-[[5-bromo-4-[[3-[[(phenylamino)carbonyl]amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide 
• 702672-43-3 [3-[[5-bromo-2-[[3-[(1-pyrrolidinylcarbonyl) amino] phenyl]amino]-4-pyrimidinyl]amino] propyl]-carbamic acid ethyl ester 
• 702672-60-4 N-[3-[[5-bromo-4-[[3-[(3-thienylmethyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide 

Relevant articles and documents

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

The design, synthesis and structure-activity relationships of a novel series of 2,4-diamino-5-cyclopropyl pyrimidines is described. Starting from BX795, originally reported to be a potent inhibitor of PDK1, we have developed compounds with improved selectivity and drug-like properties. These compounds have been evaluated in a range of cellular and in vivo assays, enabling us to probe the putative role of the TBK1/IKKε pathway in inflammatory diseases.

CHK-, PDK- AND AKT-INHIBITORY PYRIMIDINES, THEIR PRODUCTION AND USE AS PHARMACEUTICAL AGENTS

This invention relates to pyrimidine derivatives of general formula (I) as inhibitors of kinases, their production as well as their use as medications for treating various diseases.