- Synthesis of benzo[g]quinoxaline-5,10-dione based pyridine derivatives and their antimycobacterial activity
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Thirteen new compounds belonging to series 2-amino-6-(5,10-dioxo-2,3-diphenyl-5,10-dihydrobenzo[g]quinoxalin-7-yl)-4-(substituted)phenylpyridine-3-carbonitrile (6a-m) were synthesized by multistep synthetic scheme. The newly synthesized compounds were screened for their antimycobacterial activity by L.J. Slope (Conventional) Method. Compound 6h with 4-N(CH3)2 group at phenyl ring of above mentioned position has been reported as most active antimycobacterial compound and compound 6k with 4-CH3 substitution at phenyl above mentioned position has been reported as the least active antimycobacterial compound.
- Kumar, Shiv,Kumar, Nitin,Drabu, Sushma
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p. 821 - 828
(2017/05/26)
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- Synthesis and in vitro antimycobacterial activity of 7-[3-(substituted) phenylprop-2-enoyl]-2,3-diphenyl- 5H,10H-benzo[g]quinoxaline-5,10-diones
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Eleven new compounds diones namely, 7-[3-(substituted) phenylprop-2-enoyl]-2,3-diphenyl- 5H,10H-benzo[g]quinoxaline-5,10-dione (6a-k) were synthesized by multistep synthetic scheme. The newly synthesized compounds were submitted for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv by L.J. Slope (Conventional) Method. Compound 6e having 4-OCH3 at phenyl ring attached to 3-position of prop-2-enoyl group has been observed as the most active antimycobacterial compound, while compound 6h having 4-CF3 group on the above-mentioned position has been observed as the least active antimycobacterial compound of the newly synthesized series.
- Kumar, Shiv,Kumar, Nitin,Drabu, Sushma
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- Synthesis and Structure Analysis of 1,2,3,4-Tetrahydrobenzoquinoxaline-5,10-quinones
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2,3-Diamino-1,4-dihydroxynaphthalene reacts with different aromatic aldehydes to give 2,3-disubstituted 1,2,3,4-tetrahydrobenzoquinoxaline-5,10-quinones (1-7).In the course of the reaction a new C-C bond is formed stereoselectively.The yields are in th
- Haug, Juergen,Scheffler, Klaus,Stegmann, Hartmut B.,Vonwirth, Sabine,Weiss, Joachim E.,et al.
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p. 1125 - 1132
(2007/10/02)
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