- KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
-
Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
- -
-
-
- KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
-
Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
- -
-
Paragraph 0307
(2018/07/29)
-
- KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
-
Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
- -
-
Paragraph 0530
(2018/12/04)
-
- Design, synthesis of 6-substituted-pyrido[3,2-d]pyridazine derivatives with anticonvulsant activity
-
Aim to find new compounds with stronger anticonvulsant activity and lower neurotoxicity, a novel series of 6-substituted-pyrido[3,2-d]pyridazine derivatives was synthesized using furo[3,4-b]pyridine-5,7-dione as the starting material. We evaluated their a
- Dong, Zheng-Qi,Liu, Xiao-Mei,Wei, Cheng-Xi,Quan, Zhe-Shan
-
p. 595 - 601
(2015/08/18)
-
- Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines
-
Pyridopyridazine antagonists of the hedgehog signaling pathway are described. Designed to optimize our previously described phthalazine smoothened antagonists, a representative compound eliminates a PXR liability while retaining potency and in vitro metab
- Kaizerman, Jacob A.,Aaron, Wade,An, Songzhu,Austin, Richard,Brown, Matt,Chong, Angela,Huang, Tom,Hungate, Randall,Jiang, Ben,Johnson, Michael G.,Lee, Gary,Lucas, Brian S.,Orf, Jessica,Rong, Minqing,Toteva, Maria M.,Wickramasinghe, Dineli,Xu, Guifen,Ye, Qiuping,Zhong, Wendy,McMinn, Dustin L.
-
scheme or table
p. 4607 - 4610
(2010/10/02)
-
- ANNELATED PYRIDAZINES FOR THE TREATMENT OF TUMORS DRIVEN BY INAPPROPRIATE HEDGEHOG SIGNALLING
-
The present invention relates generally to compounds represented in Formula (I), pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
- -
-
Page/Page column 78
(2009/04/25)
-
- Pentaaza-cyclopental[a]naphthalene derivatives as ligands for GABAa α5 receptors
-
A class of 1,2,3a,4,x-pentaaza-cyclopenta[a]naphthalene compounds (x=6, 7, 8 or 9) is described. The compounds have a high affinity for the GABAAα5 receptors and show inverse agonist activity thereat. The compounds are useful in therapy where cognition enhancement is required.
- -
-
-
- 6-Chloro-1,2,4-triazolopyrido- and pyridazines - Synthesis and Structure determination
-
5,8-Dichloropyridopyridazine (2) gave with hydrazine hydrate in dioxane 5-chloro-8-hydrazino- and 8-chloro-5-hydrazinopyridopyridazines 3 and 4.When 3 and 4 were allowed to react with formic acid they gave a mixture of the 6-chloro-1,2,4-triazolopyrido- and pyridazines (5 and 6).
- Hassan, M. A.,Fahmy, A. F. M.
-
p. 943 - 944
(2007/10/02)
-