704910-24-7Relevant articles and documents
SPIROHYDANTOIN COMPOUNDS AND THEIR USE AS SELECTIVE ANDROGEN RECEPTOR MODULATORS
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, (2013/09/12)
The present invention relates to a compound of formula (1-1 ) in free form or in pharmaceutically acceptable salt form in which the substituents are as defined in the specification; to its preparation, to its use as a medicament and to medicaments comprising it. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Synthesis of non-THF analogs of acetogenin toward simplified mimics
Fujita, Daisuke,Ichimaru, Naoya,Abe, Masato,Murai, Masatoshi,Hamada, Takeshi,Nishioka, Takaaki,Miyoshi, Hideto
, p. 5775 - 5779 (2007/10/03)
Acetogenin analogs in which the bis-adjacent THF ring was replaced with an enantioselectively synthesized 1,2-cyclopentanediol bis-ether skeleton were synthesized to obtain simplified mimics, and their inhibitory effect on mitochondrial NADH-ubiquinone oxidoreductase (complex I) was examined. The results clearly demonstrate that the 1,2-cyclopentanediol bis-ether motif can substitute for the bis-THF ring while maintaining very potent inhibitory activity at the nanomolar level.
Enantiodifferentiating Functionalization of cis-Cycloalkane-1,2-diols and cis-endo-5-Norbornen-2,3-ylenebis(methanol) via Chiral Spiroacetals Derived from 1-Menthone
Harada, Toshiro,Wada, Isao,Oku, Akira
, p. 2599 - 2605 (2007/10/02)
The enantiodifferentiating transformation of a prochiral hydroxyl group in cis-cycloalkane-1,2-diols and cis-endo-5-norbornen-2,3-ylenebis(methanol) (16) is presented.The reactions of the bis(trimethylsilyl) derivatives of 1,2-diols 6a-d with l-menthone i