- Ar-BINMOL-derived salan-Cu(II) complex-catalyzed silyl-reformatsky reaction of aromatic aldehydes
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In this work, we have developed a facile protocol with salan-Cu system for the facile and selective synthesis of β-hydroxyesters via silyl-Reformatsky reaction with -silylester and aldehydes. The screening and optimization of reaction conditions led to the determination of a practical and efficient procedure in which the salan-Cu exhibited promising catalytic activity in dimethylsulfoxide, in which the silyl-Reformatsky reaction of aromatic aldehydes with -trimethylsilylmethylacetate gave the corresponding β-hydroxyester derivatives in excellent yields (up to 98%) under fluoride-free reaction conditions.
- Li, Fei,Zhou, Wei,Zheng, Long-Sheng,Li, Li,Zheng, Zhan-Jiang,Xu, Li-Wen
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supporting information
p. 2861 - 2869
(2014/09/17)
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- NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
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Disclosed herein are compounds of formula Ar1-X-W-Ar2 wherein Ar1 and Ar2 represent aryl groups characterized generally as aromatic heterocycles (e.g. imidazolyl or tetrazolyl) or carbocycles (e.g. phenyl or naphthalenyl); the aryl groups are optionally substituted or fused with other heterocycles or carbocycles; the aryl groups can bear substituents such as alkyl, halo or O-alkyl. X is a heteroatom, a valence bond or an optionally substituted divalent methylene, and W represents a spacer; typical spacers include divalent alkylene or alkylene-amido, -amido or -oxy radicals, which may optionally be substituted (e.g. hydroxyl or oxo). A typical compound is a derivative of 2-(N-napthalenyltetrazolylthio)- N-(2-nitrophenyl)acetamide. The compounds have inhibitory activity against Wild Type and single or double mutant strains of HIV.
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- Mesoporous silica anchored Ru catalysts for highly enantioselective hydrogenation of β-ketoesters
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Recyclable and reusable mesoporous silica anchored Ru catalysts based on 4,4′-substituted BINAPs were synthesized and used for the hydrogenation of β-alkyl β-ketoesters with up to 98.6% e.e. and β-aryl β-ketoesters with up to 95.2% e.e.
- Kesanli, Banu,Lin, Wenbin
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p. 2284 - 2285
(2007/10/03)
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