705969-09-1

Basic information

• Product Name: methyl 3-hydroxy-3-(2-chlorophenyl)propionate
• Synonyms: methyl 3-hydroxy-3-(2-chlorophenyl)propionate
• CAS NO: 705969-09-1
• Molecular Weight: 214.649
• Mol File: 705969-09-1.mol

Chemical Properties

• CAS DataBase Reference: methyl 3-hydroxy-3-(2-chlorophenyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-hydroxy-3-(2-chlorophenyl)propionate(705969-09-1)
• EPA Substance Registry System: methyl 3-hydroxy-3-(2-chlorophenyl)propionate(705969-09-1)

Safety Data

• Hazardous Substances Data: 705969-09-1(Hazardous Substances Data)

Upstream product

• 205985-98-4 methyl 2-chlorobenzoylacetate 
• 79-20-9 acetic acid methyl ester 
• 89-98-5 2-chloro-benzaldehyde 
• 2916-76-9 methyl (trimethylsilyl)acetate 

Relevant articles and documents

Ar-BINMOL-derived salan-Cu(II) complex-catalyzed silyl-reformatsky reaction of aromatic aldehydes

In this work, we have developed a facile protocol with salan-Cu system for the facile and selective synthesis of β-hydroxyesters via silyl-Reformatsky reaction with -silylester and aldehydes. The screening and optimization of reaction conditions led to the determination of a practical and efficient procedure in which the salan-Cu exhibited promising catalytic activity in dimethylsulfoxide, in which the silyl-Reformatsky reaction of aromatic aldehydes with -trimethylsilylmethylacetate gave the corresponding β-hydroxyester derivatives in excellent yields (up to 98%) under fluoride-free reaction conditions.

Mesoporous silica anchored Ru catalysts for highly enantioselective hydrogenation of β-ketoesters

Recyclable and reusable mesoporous silica anchored Ru catalysts based on 4,4′-substituted BINAPs were synthesized and used for the hydrogenation of β-alkyl β-ketoesters with up to 98.6% e.e. and β-aryl β-ketoesters with up to 95.2% e.e.

NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

Disclosed herein are compounds of formula Ar1-X-W-Ar2 wherein Ar1 and Ar2 represent aryl groups characterized generally as aromatic heterocycles (e.g. imidazolyl or tetrazolyl) or carbocycles (e.g. phenyl or naphthalenyl); the aryl groups are optionally substituted or fused with other heterocycles or carbocycles; the aryl groups can bear substituents such as alkyl, halo or O-alkyl. X is a heteroatom, a valence bond or an optionally substituted divalent methylene, and W represents a spacer; typical spacers include divalent alkylene or alkylene-amido, -amido or -oxy radicals, which may optionally be substituted (e.g. hydroxyl or oxo). A typical compound is a derivative of 2-(N-napthalenyltetrazolylthio)- N-(2-nitrophenyl)acetamide. The compounds have inhibitory activity against Wild Type and single or double mutant strains of HIV.