70705-33-8Relevant articles and documents
HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS
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Paragraph 000157; 000158, (2019/06/11)
The compounds of Formula I, Formula Ia, and Formula Ib are described herein along with their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds inhibit PRMT5 and are useful as therpeautic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer's disease, Parkinson's disease and the like.
Microwave-Assisted Suzuki–Miyaura and Sonogashira Coupling of 4-Chloro-2-(trifluoromethyl)pyrido[1,2-e]purine Derivatives
Tber, Zahira,Biteau, Nicolas G.,Agrofoglio, Luigi,Cros, Julien,Goffinont, Stéphane,Castaing, Bertrand,Nicolas, Cyril,Roy, Vincent
, p. 5756 - 5767 (2019/08/20)
The convenient preparation of three imidazo[1,2-a]pyridine-2-carboxamide intermediates is reported through known Strecker–Ugi type multicomponent reactions, Tschitschibabin type condensations, and further synthetic sequences. The derivatives were then efficiently converted to novel 4-chloro-2-(trifluoromethyl)pyrido[1,2-e]purines by their original reactions with 2,2,2-trifluoroacetamide, followed by subsequent dehydroxychlorination reactions. These compounds were cross-coupled under microwave irradiation through SuzukiMiyaura and Sonogashira palladium(0) catalysis to various aromatic and alkynyl reagents, thus providing the related C-4 substituted pyrido[1,2-e]purines of biological interest in good yields.
Discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors
Feng, Song,Hong, Di,Wang, Baoxia,Zheng, Xiufang,Miao, Kun,Wang, Lisha,Yun, Hongying,Gao, Lu,Zhao, Shuhai,Shen, Hong C.
supporting information, p. 359 - 362 (2015/03/30)
A series of imidazolepyridine derivatives were designed and synthesized according to the established docking studies. The imidazopyridine derivatives were found to have good potency and physical-chemical properties. Several highly potent compounds such as 8ji, 8jl, and 8jm were identified with single nanomolar activities. The most potent compound 8jm showed an IC50 of 3 nM, lower microsome clearance and no CYP inhibition. The profile of 8jm appeared to be superior to BMS433771, and supported further optimization.
Evaluation of catalytic activity of imidazolo[1,2-a] pyridine derivatives: Oxidation of catechol
Saddik,Khoutoul,Benchat,Hammouti,S. El Kadiri,Touzani
, p. 2457 - 2470 (2013/03/13)
A series of heterocyclic compounds possessing imidazolo[1,2-a]pyridine moiety, namely, ethyl 7-methylimidazolo[1,2-a] pyridine-2-carboxylate L1; 2-(3-nitrophenyl)imidazo[1,2-a]pyridine L2; 3-(imidazo[1,2-a]pyridine-2-yl) aniline L3; 2-phenylimidazolo[1,2-
INDOLIZINE INHIBITORS OF 5-LIPOXYGENASE
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Page/Page column 107, (2011/04/24)
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.
Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives
Xia, Guangxin,Li, Jianfeng,Peng, Aiming,Lai, Shunan,Zhang, Shujun,Shen, Jingshan,Liu, Zhonghua,Chen, Xinjian,Ji, Ruyun
, p. 2790 - 2794 (2007/10/03)
Synthesis and primary SAR of a novel series of 2-phenylpyrido[1,2-e]purin- 4(3H)-one derivatives with piperazinyl sulfonamide substituents were described herein. As potential PDE5 inhibitors for erectile dysfunction (ED) treatment, representative compound
