Welcome to LookChem.com Sign In|Join Free

CAS

  • or
7-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester is a heterocyclic chemical compound with an imidazopyridine scaffold, which is a common structural motif in pharmaceutical research and development. As an ethyl ester, it contributes to the compound's lipophilicity, potentially enhancing bioavailability. 7-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER is primarily used as a building block in the synthesis of various drug candidates.

70705-33-8

Post Buying Request

70705-33-8 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

70705-33-8 Usage

Uses

Used in Pharmaceutical Research and Development:
7-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester is used as a building block for the synthesis of drug candidates, particularly in the design of new therapeutic agents. Its imidazopyridine scaffold is a key structural element that can be further modified to create compounds with specific biological activities.
Used in Drug Design:
7-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester is used as a starting material in the development of new drugs, where its imidazopyridine core can be functionalized to achieve desired pharmacological properties. The ethyl ester group may also be utilized to improve the compound's lipophilicity, which can be beneficial for its absorption, distribution, metabolism, and excretion (ADME) properties.
Used in Heterocyclic Chemistry:
7-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester is used as a representative example of heterocyclic compounds, which are compounds containing rings made of more than one kind of atom. Its structure and properties are of interest to researchers studying the synthesis and applications of heterocyclic compounds in various fields, including materials science and medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 70705-33-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,7,0 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 70705-33:
(7*7)+(6*0)+(5*7)+(4*0)+(3*5)+(2*3)+(1*3)=108
108 % 10 = 8
So 70705-33-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2O2/c1-3-15-11(14)9-7-13-5-4-8(2)6-10(13)12-9/h4-7H,3H2,1-2H3

70705-33-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 7-methylimidazo[1,2-a]pyridine-2-carboxylate

1.2 Other means of identification

Product number -
Other names ethyl 7-methylimidazo[1,2-a]pyridine-2-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:70705-33-8 SDS

70705-33-8Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS

-

Paragraph 000157; 000158, (2019/06/11)

The compounds of Formula I, Formula Ia, and Formula Ib are described herein along with their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds inhibit PRMT5 and are useful as therpeautic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer's disease, Parkinson's disease and the like.

Microwave-Assisted Suzuki–Miyaura and Sonogashira Coupling of 4-Chloro-2-(trifluoromethyl)pyrido[1,2-e]purine Derivatives

Tber, Zahira,Biteau, Nicolas G.,Agrofoglio, Luigi,Cros, Julien,Goffinont, Stéphane,Castaing, Bertrand,Nicolas, Cyril,Roy, Vincent

, p. 5756 - 5767 (2019/08/20)

The convenient preparation of three imidazo[1,2-a]pyridine-2-carboxamide intermediates is reported through known Strecker–Ugi type multicomponent reactions, Tschitschibabin type condensations, and further synthetic sequences. The derivatives were then efficiently converted to novel 4-chloro-2-(trifluoromethyl)pyrido[1,2-e]purines by their original reactions with 2,2,2-trifluoroacetamide, followed by subsequent dehydroxychlorination reactions. These compounds were cross-coupled under microwave irradiation through SuzukiMiyaura and Sonogashira palladium(0) catalysis to various aromatic and alkynyl reagents, thus providing the related C-4 substituted pyrido[1,2-e]purines of biological interest in good yields.

Discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors

Feng, Song,Hong, Di,Wang, Baoxia,Zheng, Xiufang,Miao, Kun,Wang, Lisha,Yun, Hongying,Gao, Lu,Zhao, Shuhai,Shen, Hong C.

supporting information, p. 359 - 362 (2015/03/30)

A series of imidazolepyridine derivatives were designed and synthesized according to the established docking studies. The imidazopyridine derivatives were found to have good potency and physical-chemical properties. Several highly potent compounds such as 8ji, 8jl, and 8jm were identified with single nanomolar activities. The most potent compound 8jm showed an IC50 of 3 nM, lower microsome clearance and no CYP inhibition. The profile of 8jm appeared to be superior to BMS433771, and supported further optimization.

Evaluation of catalytic activity of imidazolo[1,2-a] pyridine derivatives: Oxidation of catechol

Saddik,Khoutoul,Benchat,Hammouti,S. El Kadiri,Touzani

, p. 2457 - 2470 (2013/03/13)

A series of heterocyclic compounds possessing imidazolo[1,2-a]pyridine moiety, namely, ethyl 7-methylimidazolo[1,2-a] pyridine-2-carboxylate L1; 2-(3-nitrophenyl)imidazo[1,2-a]pyridine L2; 3-(imidazo[1,2-a]pyridine-2-yl) aniline L3; 2-phenylimidazolo[1,2-

INDOLIZINE INHIBITORS OF 5-LIPOXYGENASE

-

Page/Page column 107, (2011/04/24)

Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.

Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives

Xia, Guangxin,Li, Jianfeng,Peng, Aiming,Lai, Shunan,Zhang, Shujun,Shen, Jingshan,Liu, Zhonghua,Chen, Xinjian,Ji, Ruyun

, p. 2790 - 2794 (2007/10/03)

Synthesis and primary SAR of a novel series of 2-phenylpyrido[1,2-e]purin- 4(3H)-one derivatives with piperazinyl sulfonamide substituents were described herein. As potential PDE5 inhibitors for erectile dysfunction (ED) treatment, representative compound

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 70705-33-8