Isolation and identification of an unusual impurity in an intermediate of Rimadyl (carprofen)
The isolation and identification of an unknown process related impurity in a key intermediate of Rimadyl (carprofen) is described. The structure of the unknown was evaluated by NMR spectral analysis and eventually confirmed by single crystal X-Ray. A re-slurry in warm acetic acid was found to reduce the level of the unknown to an acceptable level.
Tucker, John L.,DeVries, Keith M.,Hammen, Philip D.,Rose, Peter R.,Raymer, Brian K.,Rescek, Diane
p. 1681 - 1688
(2007/10/03)
PREPARATIVE ELECTROCHEMISTRY. I. A NOVEL ELECTROCHEMICAL OXIDATION OF A 1,2,3,4-TETRAHYDROCARBAZOLE TO A CARBAZOLE DERIVATIVE
Diethyl(6-chloro-1,2,3,4-tetrahydro-2-carbazolyl)methyl malonate can bee oxidized via a four electron process at a platinum electrode in 0.1 M tetraethylammonium p-toluenesulfonate in methylene chloride to diethyl(6-chloro-2-carbazolyl)methyl malonate in 15percent yield.
Reymond, Gilbert,Vasilevskis, Janis,Toome, Voldemar
p. 2345 - 2347
(2007/10/02)
Process of making 6-chloro-α-methyl-carbazole-2-acetic acid
The aromatization of (6-chloro-1,2,3,4-tetrahydro-2-carbazolyl)-methyl-malonic acid dialkyl ester, utilizing chlorine and subsequent conversion of the resulting product to 6-chloro-α-methyl-carbazole-2-acetic acid by hydrolysis and decarboxylation are described.
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(2008/06/13)
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