- Synthesis and characterization of new azo dyes based on thiazole and assess the biological and laser efficacy for them and study their dyeing application
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The aim of this work describes the synthesis of disperse dyes in the derivative of 2-amino -4-hydroxy thiazole, which can be used as dyes for polyester fabrics with orange and red color They were obtained by preparing, (2-amino-4- hydroxy- thiazole), then the latter compound was diazotization and couplings to produced (compound III and IV), Which were introduced by another coupling with diazonium salt of compound I diazotization to synthesize disperse (VII,VIII). The synthesized heterocyclic and synthesized dyes were studied by UV Spectroscopy, FT-IR, 1H-NMR and 13C-NMR. The substituted dyes Penetrate with good depth on polyester fabrics with a shade of orange and red colors, respectively. That increase heteroatoms and the conjugation in the dyes structure lead to high redshifts and the brightness of shades, color stability is high and fastness properties. The antibacterial activities were studied against different kinds of bacteria, namely Eschershia coli and Klebsiella Pneumonia Gram (-) ve, Staphylococcus aureus and Staphylococcus epidermidis Gram (+) ve. In addition, evaluation of laser efficacy was showed for the compounds (I,III,IV,VII,VIII) were radiated by laser for (10, 20, 30) seconds, It was observed that the prepared compounds were not affected and did not polymerize or degradation when measuring melting point and color.
- Aftan, Mohammed M.,Toma, Manal A.,Dalaf, Adil H.,Abdullah, Ebtihal Q.,Salih, Hanaa K.
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p. 2903 - 2911
(2021/05/28)
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- Development of a potential manufacturing route to PF-00610355: A novel inhaled β2-adrenoreceptor agonist
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The development of a practical, scalable route to PF-00610355 (8) is described. In this convergent approach, amine 9 is coupled to protected bromohydrin 1 to give the doubly protected intermediate 26. TBS-Deprotection of 26 affords the benzyl protected pe
- De Koning, Pieter D.,Castro, Nieves,Gladwell, Iain R.,Morrison, Natalie A.,Moses, Ian B.,Panesar, Maninder S.,Pettman, Alan J.,Thomson, Nicholas M.
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experimental part
p. 1256 - 1265
(2012/02/05)
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- The synthesis of two potent β-3 adrenergic receptor agonists
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This contribution describes the initial preparation of two potent β-3 receptor agonists 1 and 2. Subsequent scale up of these two compounds was required for further evaluation and proceeded via a common key amine intermediate 24. Synthesis of this key intermediate by way of a Ritter reaction was a vital step in the sequence. Enantioselective Noyori hydrogenation reactions gave access to the chiral epoxides necessary to make the target compounds. Chemistry was developed for the selective dehalogenation of the 2-chloropyridyl group in the presence of a sensitive isoxazole unit to provide access to 1.
- Bradley, Paul A.,Lecouturier, Yann C.,Noeureuil, Pierre,Patel, Bhairavi,Wheeler, Simon,Carroll, Robert J.,Moore, Robert,Snow, Jonathan
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experimental part
p. 1326 - 1336
(2011/09/20)
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