- Preparation method of dichlorotoluene nitride intermediate
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The invention belongs to the technical field of preparation of pesticide intermediates, and particularly discloses a preparation method of a dichlorotoluene nitride intermediate. The preparation method comprises the following steps: fully reacting raw materials, a solvent and a nitration reagent to obtain a dichlorotoluene nitride intermediate, wherein the raw materials comprise any one of o-dichlorotoluene, m-dichlorotoluene and p-dichlorotoluene; the solvent is dichloroethane; the nitration reagent is concentrated nitric acid; the dichlorotoluene nitride intermediate is shown as a chemical formula 7 and a chemical formula 12. The preparation method has the advantages that the corrosion to reaction equipment is less, and the generation and discharge of waste acid and waste salt in the production process are greatly reduced.
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Sheet 0050-0052; 0054-0057; 0065
(2021/01/28)
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- Bis(dealkoxycarbonylation) of nitroarylmalonates: A facile entry to alkylated nitroaromatics
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A simple approach to alkylated nitroaromatics from substituted nitroaryl malonic esters by double decarboxylation is detailed.
- Gurjar,Reddy,Murugaiah,Murugaiah
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p. 1659 - 1661
(2007/10/03)
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- A novel synthesis of the antipsychotic agent ziprasidone
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A new synthesis of the antipsychotic ziprasidone from 2,5-dichloro-4-nitrotoluene 3 is presented. The nitro group in 3 was used to activate the orthochlorine for displacement and the methyl group for enamine formation and introduction of the piperazinyl moiety.
- Urban, Frank J.,Breitenbach, Ralph,Gonyaw, Dianne
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p. 1629 - 1638
(2007/10/03)
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- Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one
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A process for preparing the compound of the formula STR1 which comprises treating a compound of the formula STR2 wherein R2 is hydrogen, CN or CO2 R1 and R1 is hydrogen or (C1 -C6)alkyl with a reducing agent with the proviso that when R2 is CN or CO2 R1 and R1 is (C1 -C6)alkyl the product of the reduction is heated with an acid. Compounds of formula II wherein R2 is CN or CO2 R1 and R1 is (C1 -C6)alkyl or R2 is hydrogen and R1 is (C1 -C6)alkyl or hydrogen. The compound of formula VII R1 is (C1 -C6)alkyl. The compound of formula III. The compound of formula I is useful in the treatment of psychotic disorders.
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- A practical synthesis of 2,4-dichloro-3-methyl-6-nitrophenol
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2,4-Dichloro-3-methyl-6-nitrophenol 2 was prepared by KOH/H2O hydrolysis of a product mixture obtained from chlorination of p-nitrotoluene in the presence of a phase transfer catalyst. A 95-99% yield of 2 based on 2,3,6-trichloro-4-nitrotoluene, 4 (major chlorination product) was achieved in >95% purity.
- Ran,Pittman Jr.
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p. 2785 - 2795
(2007/10/02)
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