7149-76-0

Basic information

• Product Name: 1,4-dichloro-2-methyl-5-nitro-benzene
• Synonyms: 2,5-DICHLORO-4-NITROTOLUENE;1-Nitro-4-methyl-2,5-dichlorobenzene;1,4-DICHLORO-2-METHYL-5-NITRO-BENZENE;Benzene, 1,4-dichloro-2-Methyl-5-nitro-
• CAS NO: 7149-76-0
• Molecular Formula: C₇H₅Cl₂NO₂
• Molecular Weight: 206.0261
• Mol File: 7149-76-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 292.6°Cat760mmHg
• Flash Point: 130.8°C
• Appearance: /
• Density: 1.456g/cm³
• Vapor Pressure: 0.00318mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 1,4-dichloro-2-methyl-5-nitro-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dichloro-2-methyl-5-nitro-benzene(7149-76-0)
• EPA Substance Registry System: 1,4-dichloro-2-methyl-5-nitro-benzene(7149-76-0)

Safety Data

• Hazardous Substances Data: 7149-76-0(Hazardous Substances Data)

Usage

General Description

1,4-dichloro-2-methyl-5-nitro-benzene is a chemical compound with the molecular formula C7H5Cl2NO2. It is a yellow crystalline solid that is insoluble in water but soluble in organic solvents. 1,4-dichloro-2-methyl-5-nitro-benzene is commonly used in the production of pharmaceuticals, dyes, and pesticides. It is also used as an intermediate in the synthesis of other organic compounds. 1,4-dichloro-2-methyl-5-nitro-benzene is considered to be hazardous to the environment and human health, as it is a potential environmental contaminant and has toxic effects on aquatic organisms. Therefore, proper handling and disposal of this chemical are necessary to prevent harm to the environment and human health.

InChI:InChI=1/C7H5Cl2NO2/c1-4-2-6(9)7(10(11)12)3-5(4)8/h2-3H,1H3

Upstream product

• 19398-61-9 2,5-dichlorotoluene 
• 95-69-2 4-chloro-2-methylbenzeneamine 
• 56136-79-9 2-chloro-4,5-dinitro-toluene 
• 95-49-8 2-methylchlorobenzene 
• 121-86-8 2-chloro-4-nitrotoluene 
• 89-69-0 2,4,5-Trichloronitrobenzene 
• 996-82-7 sodium diethylmalonate 
• 99-99-0 1-methyl-4-nitrobenzene 
• 7149-73-7 4-chloro-5-methyl-2-nitro-aniline 

Downstream Products

• 160384-45-2 methyl (5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-4-chloro-2-nitrophenyl)-cyanoacetate 
• 160384-39-4 5-Chloro-4-(2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl)-2-(bis-(methoxycarbonyl)methyl)-nitrobenzene 
• 160384-41-8 methyl 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-4-chloro-2-nitrophenyl acetate 
• 160384-40-7 5-(2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl)-4-chloro-2-nitrophenyl acetic acid 
• 160384-37-2 2,5-Dichloro-4-(2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethenyl)-nitrobenzene 
• 122883-93-6 ziprazidone 
• 89267-33-4 1-(4-chloro-5-methyl-2-nitro-anilino)-D-1-deoxy-ribitol 
• 56223-76-8 N'-(4-Chloro-5-methyl-2-nitro-phenyl)-N,N-diethyl-ethane-1,2-diamine 
• 65273-36-1 2-[[2-(4-Chloro-5-methyl-2-nitro-phenylamino)-ethyl]-(2-hydroxy-ethyl)-amino]-ethanol 
• 88434-66-6 2,5-dichloro-4-methyl-aniline 
• 13300-60-2 2,5-dichloro-4-nitro-benzoic acid 

Relevant articles and documents

Preparation method of dichlorotoluene nitride intermediate

The invention belongs to the technical field of preparation of pesticide intermediates, and particularly discloses a preparation method of a dichlorotoluene nitride intermediate. The preparation method comprises the following steps: fully reacting raw materials, a solvent and a nitration reagent to obtain a dichlorotoluene nitride intermediate, wherein the raw materials comprise any one of o-dichlorotoluene, m-dichlorotoluene and p-dichlorotoluene; the solvent is dichloroethane; the nitration reagent is concentrated nitric acid; the dichlorotoluene nitride intermediate is shown as a chemical formula 7 and a chemical formula 12. The preparation method has the advantages that the corrosion to reaction equipment is less, and the generation and discharge of waste acid and waste salt in the production process are greatly reduced.

A novel synthesis of the antipsychotic agent ziprasidone

A new synthesis of the antipsychotic ziprasidone from 2,5-dichloro-4-nitrotoluene 3 is presented. The nitro group in 3 was used to activate the orthochlorine for displacement and the methyl group for enamine formation and introduction of the piperazinyl moiety.

A practical synthesis of 2,4-dichloro-3-methyl-6-nitrophenol

2,4-Dichloro-3-methyl-6-nitrophenol 2 was prepared by KOH/H2O hydrolysis of a product mixture obtained from chlorination of p-nitrotoluene in the presence of a phase transfer catalyst. A 95-99% yield of 2 based on 2,3,6-trichloro-4-nitrotoluene, 4 (major chlorination product) was achieved in >95% purity.