- Synthesis of the lipophilic antifolate piritrexim via a palladium(0)-catalyzed cross-coupling reaction
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(Chemical Equation Presented) A regiospecific and convergent route the lipophilic antifolate piritrexim (PTX) is described in which a key step is a Pd(0)-catalyzed cross-coupling reaction between 2-amino-3-cyano-4-methyl-5- bromopyridine and 2,5-dimethoxy
- Chan, David C. M.,Rosowsky, Andre
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p. 1364 - 1368
(2007/10/03)
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- SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE
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A method for making 3-amino-2-chloro-4-methylpyridine from malononitrile, as depicted in the following reaction scheme.
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- 2,4-diamino-5,6-disubstituted- and 5,6,7-trisubstituted 5-deazapteridines as insecticides
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An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a 5-deazapteridine compound of the formula: STR1 wherein R1, R2, R3, R4, U, V, and W are as defined herein; agriculturally acceptable salts thereof; methods for using the same; and certain novel 5-deazapteridines per se.
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- Substituted 2-aminonicotinonitriles
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Aminolysis of the cyanoketene-O,N-acetal 1 Z/E with the amines 2a,b leads to the E-configurated cyanoketeneaminals 3a,b. Compounds 3a,b are reacted with 1,3-biselectrophiles 4, 6a,b, 9 HCl, 12, 13, 15a,b, 17, and 19 to yield the N2-substituted 2-aminonicotinonitriles 5, 7, 8, 10, 11, 14, 16, and 20. Reaction of some 2-aminonicotinonitriles with an α-phenylethyl substituent in position 2 (14b, 16a, 8a, 20b, 5 and 8b) with PPA leads to the primary 2-aminonicotinonitriles 21a-f.
- Troschutz,Dennstedt
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- ACETALS OF LACTAMS AND ACID AMIDES: 42.* CYCLIZATION OF DIENAMINO ESTERS; DIENOAMINE NITRILES; AND ACYLAMIDINES TO PYRIDINE DERIVATIVES
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The reaction of derivatives of alkylidene(cycloalkylidene)cyanoacetic ester, -malonodinitrile , and -cyanoacetamide with dimethylformamide diethylacetal with subsequent cyclization of the resulting enamine systems gives derivatives of pyridine, 2-pyridine, and isoquinoline. 2-Amino-3-cyano-4-methylpyridine, which was synthesized by this method, was converted to a pyridopyrimidine derivative.
- Smetskaya, N. I.,Mukhina, N. A.,Granik, V. G.
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p. 650 - 653
(2007/10/02)
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