71493-76-0

Basic information

• Product Name: 2-AMINO-3-CYANO-4-METHYLPYRIDINE
• Synonyms: 2-AMINO-3-CYANO-4-METHYLPYRIDINE;2-AMINO-3-CYANO-4-PICOLINE;2-amino-4-methylpyridine-3-carbonitrile;2-Amino-4-methylpyridine-3-carbonitrile, 2-Amino-3-cyano-4-methylpyridine;2-aMino-4-Methyl-3-Pyridinecarbonitrile
• CAS NO: 71493-76-0
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.15058
• Product Categories: Pyridine
• Mol File: 71493-76-0.mol

Chemical Properties

• Melting Point: 154-155 °C(Solv: ethyl acetate (141-78-6); cyclohexane (110-82-7))
• Boiling Point: 306.338 °C at 760 mmHg
• Flash Point: 139.069 °C
• Appearance: /
• Density: 1.184 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.65±0.47(Predicted)
• CAS DataBase Reference: 2-AMINO-3-CYANO-4-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-CYANO-4-METHYLPYRIDINE(71493-76-0)
• EPA Substance Registry System: 2-AMINO-3-CYANO-4-METHYLPYRIDINE(71493-76-0)

Safety Data

• Hazardous Substances Data: 71493-76-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-3-CYANO-4-METHYLPYRIDINE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-AMINO-3-CYANO-4-METHYLPYRIDINE serves as an intermediate in the production of agrochemicals, potentially enhancing crop protection and management through the development of novel compounds.
Used in Antiviral Applications:
2-AMINO-3-CYANO-4-METHYLPYRIDINE is studied for its potential use as an antiviral agent, indicating its possible role in the development of treatments for viral infections.
Used in Antitumor Applications:
2-AMINO-3-CYANO-4-METHYLPYRIDINE is also being investigated for its potential as an antitumor agent, suggesting its possible contribution to cancer therapy and the development of new oncology drugs.
Used in Chemical Research:
Due to its unique chemical structure, 2-AMINO-3-CYANO-4-METHYLPYRIDINE is utilized in chemical research to explore new reactions and mechanisms, potentially leading to advancements in synthetic chemistry and material science.

InChI:InChI=1/C7H7N3/c1-5-2-3-10-7(9)6(5)4-8/h2-3H,1H3,(H2,9,10)

Upstream product

• 65995-95-1 2-(3-ethoxy-1-methyl-(E)-2-propenylidene)malononitrile 
• 65995-94-0 2-(3.3-diethoxy-1-methylpropylidene)malononitrile 
• 180994-86-9 1,1-dicyano-4,4-diethoxy-3-methyl-1-butene 
• 65995-93-9 1,1-dicyano-4-ethoxy-3-methyl-1,3-butadiene 
• 410547-37-4 4,4-dicyano-3-methyl-3-butenal dimethyl acetal 
• 544-92-3 copper(I) cyanide 
• 40073-38-9 2-amino-3-bromo-4-methylpyridine 
• 154420-79-8 (+/-)-4-Methyl-2-(1-phenylethylamino)nicotinonitril 
• 71493-72-6 2-(4-(dimethylamino)but-3-en-2-ylidene)malononitrile 

Downstream Products

• 38076-82-3 2-amino-4-methylnicotinic acid 
• 1352888-45-9 7-methylimidazo[1,2-a]pyridine-8-carbonitrile 
• 93271-59-1 2-hydroxy-4-methylpyridine-3-carbonitrile 
• 72732-56-0 piritrexim 
• 153944-51-5 2-bromo-3-cyano-4-methyl-5-(2,5-dimethoxybenzyl)pyridine 
• 847234-66-6 2-amino-3-cyano-4-methyl-5-(2,5-dimethoxybenzyl)pyridine 
• 180995-02-2 2-amino-3-cyano-4-methyl-5-iodopyridine 
• 180994-87-0 2-amino-3-cyano-4-methyl-5-bromopyridine 

Relevant articles and documents

Synthesis of the lipophilic antifolate piritrexim via a palladium(0)-catalyzed cross-coupling reaction

(Chemical Equation Presented) A regiospecific and convergent route the lipophilic antifolate piritrexim (PTX) is described in which a key step is a Pd(0)-catalyzed cross-coupling reaction between 2-amino-3-cyano-4-methyl-5- bromopyridine and 2,5-dimethoxy

SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE

A method for making 3-amino-2-chloro-4-methylpyridine from malononitrile, as depicted in the following reaction scheme.

2,4-diamino-5,6-disubstituted- and 5,6,7-trisubstituted 5-deazapteridines as insecticides

An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a 5-deazapteridine compound of the formula: STR1 wherein R1, R2, R3, R4, U, V, and W are as defined herein; agriculturally acceptable salts thereof; methods for using the same; and certain novel 5-deazapteridines per se.

Substituted 2-aminonicotinonitriles

Aminolysis of the cyanoketene-O,N-acetal 1 Z/E with the amines 2a,b leads to the E-configurated cyanoketeneaminals 3a,b. Compounds 3a,b are reacted with 1,3-biselectrophiles 4, 6a,b, 9 HCl, 12, 13, 15a,b, 17, and 19 to yield the N2-substituted 2-aminonicotinonitriles 5, 7, 8, 10, 11, 14, 16, and 20. Reaction of some 2-aminonicotinonitriles with an α-phenylethyl substituent in position 2 (14b, 16a, 8a, 20b, 5 and 8b) with PPA leads to the primary 2-aminonicotinonitriles 21a-f.

ACETALS OF LACTAMS AND ACID AMIDES: 42.* CYCLIZATION OF DIENAMINO ESTERS; DIENOAMINE NITRILES; AND ACYLAMIDINES TO PYRIDINE DERIVATIVES

The reaction of derivatives of alkylidene(cycloalkylidene)cyanoacetic ester, -malonodinitrile , and -cyanoacetamide with dimethylformamide diethylacetal with subsequent cyclization of the resulting enamine systems gives derivatives of pyridine, 2-pyridine, and isoquinoline. 2-Amino-3-cyano-4-methylpyridine, which was synthesized by this method, was converted to a pyridopyrimidine derivative.