71493-76-0

Basic information

• Product Name: 2-AMINO-3-CYANO-4-METHYLPYRIDINE
• Synonyms: 2-AMINO-3-CYANO-4-METHYLPYRIDINE;2-AMINO-3-CYANO-4-PICOLINE;2-amino-4-methylpyridine-3-carbonitrile;2-Amino-4-methylpyridine-3-carbonitrile, 2-Amino-3-cyano-4-methylpyridine;2-aMino-4-Methyl-3-Pyridinecarbonitrile
• CAS NO: 71493-76-0
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.15058
• Product Categories: Pyridine
• Mol File: 71493-76-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 154-155 °C(Solv: ethyl acetate (141-78-6); cyclohexane (110-82-7))
• Boiling Point: 306.338 °C at 760 mmHg
• Flash Point: 139.069 °C
• Appearance: /
• Density: 1.184 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.65±0.47(Predicted)
• CAS DataBase Reference: 2-AMINO-3-CYANO-4-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-CYANO-4-METHYLPYRIDINE(71493-76-0)
• EPA Substance Registry System: 2-AMINO-3-CYANO-4-METHYLPYRIDINE(71493-76-0)

Safety Data

• Hazardous Substances Data: 71493-76-0(Hazardous Substances Data)

Usage

General Description

2-AMINO-3-CYANO-4-METHYLPYRIDINE is a chemical compound with the molecular formula C7H6N3. It is a pyridine derivative with a methyl group and a cyano group attached to the 3rd and 4th carbon atoms, and an amino group attached to the 2nd carbon atom. 2-AMINO-3-CYANO-4-METHYLPYRIDINE is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential use as an antiviral and antitumor agent. 2-AMINO-3-CYANO-4-METHYLPYRIDINE has a range of applications in the fields of medicine and chemistry due to its unique chemical structure and properties.

InChI:InChI=1/C7H7N3/c1-5-2-3-10-7(9)6(5)4-8/h2-3H,1H3,(H2,9,10)

Upstream product

• 544-92-3 copper(I) cyanide 
• 40073-38-9 2-amino-3-bromo-4-methylpyridine 
• 65995-95-1 2-(3-ethoxy-1-methyl-(E)-2-propenylidene)malononitrile 
• 65995-94-0 2-(3.3-diethoxy-1-methylpropylidene)malononitrile 
• 180994-86-9 1,1-dicyano-4,4-diethoxy-3-methyl-1-butene 
• 65995-93-9 1,1-dicyano-4-ethoxy-3-methyl-1,3-butadiene 
• 410547-37-4 4,4-dicyano-3-methyl-3-butenal dimethyl acetal 
• 154420-79-8 (+/-)-4-Methyl-2-(1-phenylethylamino)nicotinonitril 
• 71493-72-6 2-(4-(dimethylamino)but-3-en-2-ylidene)malononitrile 

Downstream Products

• 180994-87-0 2-amino-3-cyano-4-methyl-5-bromopyridine 
• 180995-02-2 2-amino-3-cyano-4-methyl-5-iodopyridine 
• 93271-59-1 2-hydroxy-4-methylpyridine-3-carbonitrile 
• 38076-82-3 2-amino-4-methylnicotinic acid 
• 1352888-45-9 7-methylimidazo[1,2-a]pyridine-8-carbonitrile 
• 72732-56-0 piritrexim 
• 153944-51-5 2-bromo-3-cyano-4-methyl-5-(2,5-dimethoxybenzyl)pyridine 
• 847234-66-6 2-amino-3-cyano-4-methyl-5-(2,5-dimethoxybenzyl)pyridine 

Relevant articles and documents

Synthesis of the lipophilic antifolate piritrexim via a palladium(0)-catalyzed cross-coupling reaction

(Chemical Equation Presented) A regiospecific and convergent route the lipophilic antifolate piritrexim (PTX) is described in which a key step is a Pd(0)-catalyzed cross-coupling reaction between 2-amino-3-cyano-4-methyl-5- bromopyridine and 2,5-dimethoxy

2,4-diamino-5,6-disubstituted- and 5,6,7-trisubstituted 5-deazapteridines as insecticides

An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a 5-deazapteridine compound of the formula: STR1 wherein R1, R2, R3, R4, U, V, and W are as defined herein; agriculturally acceptable salts thereof; methods for using the same; and certain novel 5-deazapteridines per se.

Substituted 2-aminonicotinonitriles

Aminolysis of the cyanoketene-O,N-acetal 1 Z/E with the amines 2a,b leads to the E-configurated cyanoketeneaminals 3a,b. Compounds 3a,b are reacted with 1,3-biselectrophiles 4, 6a,b, 9 HCl, 12, 13, 15a,b, 17, and 19 to yield the N2-substituted 2-aminonicotinonitriles 5, 7, 8, 10, 11, 14, 16, and 20. Reaction of some 2-aminonicotinonitriles with an α-phenylethyl substituent in position 2 (14b, 16a, 8a, 20b, 5 and 8b) with PPA leads to the primary 2-aminonicotinonitriles 21a-f.