- Preparation process of milrinone
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The invention discloses a preparation method of milrinone, and belongs to the technical field of drug synthesis. According to the method, 1-(4-pyridyl)-2-acetone is used as a raw material and is subjected to a heating reaction with alpha-(substituted methylene) cyanoacetamide under an alkaline condition, and milrinone is obtained. The method for preparing milrinone is simple and convenient to operate, high in safety, high in yield and suitable for industrial large-scale production. The appearance and the purity of the obtained milrinone finished product both reach the standard.
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Paragraph 0088-0093
(2021/10/13)
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