71636-61-8

Basic information

• Product Name: (+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
• Synonyms: (+/-)-6-CHLORO-PB HYDROBROMIDE;(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE;6-CHLORO-2,3,4,5-TETRAHYDRO-1-PHENYL-1H-3-BENZAZEPINE-7,8-DIOL HYDROBROMIDE;(+/-)-SKF-81297 HYDROBROMIDE;SKF 81297 HYDROBROMIDE;sk&f81297;(+-)-6-CHLORO-PB HYDROBROMIDE (+-)-SKF-8 1297, HCL;6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepinehydrobromide
• CAS NO: 71636-61-8
• Molecular Formula: C₁₆H₁₆ClNO₂
• Molecular Weight: 370.67
• Product Categories: Dopamine receptor
• Mol File: 71636-61-8.mol

Chemical Properties

• Boiling Point: 467.3 °C at 760 mmHg
• Flash Point: 236.4 °C
• Appearance: gray/solid
• Density: 1.299 g/cm³
• Vapor Pressure: 2.35E-09mmHg at 25°C
• Storage Temp.: Desiccate at +4°C
• Solubility: H2O: 1.7 mg/mL
• CAS DataBase Reference: (+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE(71636-61-8)
• EPA Substance Registry System: (+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE(71636-61-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-26-36
• WGK Germany: 3
• Hazardous Substances Data: 71636-61-8(Hazardous Substances Data)

Usage

Uses

Used in Neuroscience Research:
(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE is used as a dopamine D1 receptor (Drd1a) agonist for studying the role of the drd1a-dopamine receptor in the inactivation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. This application helps researchers understand the underlying mechanisms of dopamine receptor signaling and its impact on neuronal function.
Used in Behavioral Studies:
In the field of behavioral neuroscience, (±)-6-Chloro-PB hydrobromide is used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in the Barnes maze in rats. This application aids in understanding the cognitive effects of dopamine receptor activation and its potential implications for the development of therapeutic strategies for cognitive disorders.
Used in Pharmaceutical Development:
(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE may also be used in the development of new pharmaceuticals targeting dopamine receptors. Its agonistic properties can be exploited to design drugs that modulate dopaminergic signaling, potentially leading to treatments for various neurological and psychiatric disorders, such as Parkinson's disease, schizophrenia, and attention deficit hyperactivity disorder (ADHD).
Used in Drug Delivery Systems:
Similar to gallotannin, (±)-6-Chloro-PB hydrobromide could potentially be incorporated into drug delivery systems to enhance its bioavailability and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the compound's delivery, efficacy, and targeting to specific cellular receptors can be improved, leading to more effective treatments for related conditions.

Biological Activity

Dopamine D 1 -like receptor agonist. Centrally active following systemic administration in vivo .

Biochem/physiol Actions

(+/-)-6-Chloro-PB HBr is a full D1 dopamine receptor agonist.

InChI:InChI=1/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H

Upstream product

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