7537-07-7

Usage

Uses

Used in Pharmaceutical Industry:
(2-chloro-3,4-dimethoxyphenyl)acetonitrile is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, (2-chloro-3,4-dimethoxyphenyl)acetonitrile serves as an essential component in the production of agrochemicals, aiding in the creation of effective pest control agents and other agricultural products.
Used in Dye and Pigment Industry:
(2-chloro-3,4-dimethoxyphenyl)acetonitrile is utilized as an intermediate in the manufacturing process of dyes and pigments, contributing to the coloration and stability of these products in various applications.
Safety Precautions:
Due to its hazardous nature, (2-chloro-3,4-dimethoxyphenyl)acetonitrile can cause skin and eye irritation upon contact. It is crucial to handle this chemical with care and adhere to proper safety precautions and handling procedures to minimize risks during its use in various industries.

InChI:InChI=1/C10H10ClNO2/c1-13-8-4-3-7(5-6-12)9(11)10(8)14-2/h3-4H,5H2,1-2H3

Upstream product

• 93983-14-3 2-chloro-3,4-dimethoxybenzyl chloride 
• 143-33-9 sodium cyanide 
• 151-50-8 potassium cyanide 
• 621-59-0 isovanillin 
• 5417-17-4 2-chloro-3,4-dimethoxybenzaldehyde 
• 37687-57-3 2-chloro-3-hydroxy-4-methoxybenzaldehyde 
• 93983-13-2 2-chloro-3,4-dimethoxybenzyl alcohol 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 67287-36-9 2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 
• 7537-11-3 2-(2-Chloro-3,4-dimethoxy-phenyl)-3-oxo-butyronitrile 
• 71636-61-8 (+-)-6-chloro-7, 8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 67227-56-9 fenoldopam 
• 7537-15-7 1-(2-Chloro-3,4-dimethoxy-phenyl)-propan-2-one 
• 102851-73-0 N-propyl-2-chlorodopamine 
• 102851-72-9 N-ethyl-2-chlorodopamine 
• 102851-71-8 N-methyl-2-chlorodopamine 
• 102851-70-7 2-chlorodopamine 
• 99318-58-8 N-(2-chlorohomoveratryl)propanamide 
• 102851-64-9 2-chlorohomoveratrylacetamide 
• 102851-63-8 (2-chlorohomoveratryl)formamide 
• 99318-59-9 N-(n-propyl)-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 
• 102851-66-1 N-ethyl-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 

Relevant academic research and scientific papers

Heterocyclic compounds

The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally having substituent(s) etc., X is an amino group optionally having substituent(s), Y1 and Y2 are nitrogen atoms etc., an isomer or solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient.

Synthesis and Renal Vasodilator Activity of 2-Chlorodopamine and N-Substituted Derivatives

A four-step synthesis of 2-chlorodopamine (2b) is presented as well as methods for the syntheses of the N-methyl, ethyl, and n-propyl analogues (2c-e).Compounds 2b and 2c were essentially equipotent to dopamine for increasing renal blood flow in anesthesized dogs that had been treated with the α-adrenergic antagonist phenoxybenzamine.The increases in renal blood flow were blocked by the DA1 antagonist (R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine.Compounds 2d and 2e were significantly less potent than dopamine in the same model; the increases in renal blood flow were attenuated by propanolol and blocked by a combination of propanolol and (R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine.The significance of an o-chloro substituent on dopamine analogues for the activation of the DA1 receptor is briefly discussed.