71985-80-3

Basic information

• Product Name: 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE
• Synonyms: BIO-FARMA BF002150;4-CARBOXY-1-METHYL-PIPERIDINE HCL;1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID HCL;1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE;1-METHYLPIPERIDINO-4-CARBOXYLIC ACID HYDROCHLORIDE;1-METHYL-4-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE;TIMTEC-BB SBB003751;RARECHEM AH CK 0139
• CAS NO: 71985-80-3
• Molecular Formula: C₇H₁₄NO₂*Cl
• Molecular Weight: 179.64
• Product Categories: Piperidine
• Mol File: 71985-80-3.mol

Chemical Properties

• Melting Point: 226-228°C (dec.)
• Boiling Point: 246.1 °C at 760 mmHg
• Flash Point: 102.6 °C
• Appearance: /
• Vapor Pressure: 0.00899mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE(71985-80-3)
• EPA Substance Registry System: 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE(71985-80-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-24/25-36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 71985-80-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

InChI:InChI=1/C7H13NO2.ClH/c1-8-4-2-6(3-5-8)7(9)10;/h6H,2-5H2,1H3,(H,9,10);1H

Upstream product

• 498-94-2 isonipecotic acid 
• 50-00-0 formaldehyd 
• 24252-37-7 ethyl 1-methylisonipecotate 

Downstream Products

• 1690-75-1 1-methyl-piperidine-4-carboxylic acid methyl ester 
• 50675-21-3 N-methyl-piperidine-4-carboxaldehyde 
• 874347-42-9 C₁₅H₂₄N₂O 
• 891269-67-3 4-({[(1S)-1-(4,5-diphenyl-1,3-oxazol-2-yl)-7-oxooctyl]amino}-carbonyl)-1-methylpiperidinium trifluoroacetate 
• 1160829-36-6 {4-[3-(1H-benzoimidazol-2-yl)-phenyl]-piperazin-1-yl}-(1-methyl-piperidin-4-yl)-methanone 
• 1187529-71-0 1-Methyl-piperidine-4-carboxylic acid [2-(2-methoxy-benzylamino)-quinolin-6-yl]-amide 
• 851012-80-1 1-methyl-piperidine-4-carboxylic acid (2-bromo-phenyl)-amide 
• 1062160-77-3 1-methyl-N-[4-(4-morpholin-4-yl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl]piperidine-4-carboxamide 
• 1404055-14-6 4-((bis(3-fluorophenyl)methoxy)carbonyl)-1-methyl-1-(2-oxo-2-(thiophen-2-yl)ethyl)piperidinium chloride 

Relevant articles and documents

PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACE

The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms made by these processe

2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS

The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof: wherein: R1, R2, R3, R4, R5, R6, R7, R8, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in the manufacture of medicaments for use in the prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

COMPOSITIONS AND METHODS OF SYNTHESIS OF PYRIDINOYLPIPERIDINE 5-HT1F AGONISTS

The present invention provides a novel polymorph of the hemisuccinate salt of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide (Form A) characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry

NON-PEPTIDYL, POTENT, AND SELECTIVE MU OPIOID RECEPTOR ANTAGONISTS

Selective, non-peptide antagonists of the ma opioid receptor { MOR) and methods of their use are provided. The antagonists may be used, for example, to identify MOR agonists in competitive binding assays, and to treat conditions related to addiction in which MOR is involved, e.g. heroin, prescription drug and alcohol addiction.

Pyrrole derivatives, their preparation and pharmaceutical compositions which contain them

This invention relates to pyrrole derivatives of formula: STR1 in which A forms with the pyrrole ring an isoindoline, 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine, 2,3,6,7-tetrahydro-5H-[1,4]oxathiino[2,3-c]pyrrole or 2,3,6,7-tetrahydro-5H-[1,4]dithiino[2,3-c]pyrrole ring-system and Hetis naphthyridinyl, pyridyl or quinolyl which is unsubstituted or substituted with halogen, (1 to 4 C) alkyl, (1 to 4 C) alkyloxy, (1 to 4 C) alkylthio or CF3 and R=(3 to 10 C) straight- or branched-chain alkenyl or alkyl which is unsubstituted or substituted with alkyloxy, alkylthio, (3 to 6 C) cycloalkyl, NH2, alkylamino, dialkylamino, alkylcarbonylamino, (in which the amino portion is optionally substituted with alkyl), 1- or 2-piperazinyl, piperidyl, piperidino, morpholino, pyrrolidinyl, 1-azetidinyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, (1-piperazinyl)carbonyl, piperidinocarbonyl, (1-pyrrolidinyl)carbonyl, phenyl, pyridyl, 1-imidazolyl, or alternatively R=2- or 3-pyrrolidinyl, 2-, 3- or 4-piperidyl, on the understanding that the alkyl radicals are straight- or branched-chain radicals and contain, except where specifically stated, 1 to 10 C, and that the piperazinyl, piperidino, piperidyl, pyrrolidinyl and azetidinyl radicals can be unsubstituted or substituted at any position with alkyl, alkylcarbonyl, benzyl or hydroxyalkyl, or can alternatively form a lactam group with the nitrogen atom of the ring, and, where they exist, their pharmaceutically acceptable salts and optical isomers, are useful as anxiolytics.

Approaches to Protection against Nerve Agent Poisoning. (Naphthylvinyl)pyridine Derivatives as Potential Antidotes

Analogues of the potent inhibitor of choline acetyltransferase (CAT) (E)-4-(1-naphthylvinyl)pyridine methiodide were synthesized and evaluated for their ability to inhibit CAT and protect against nerve agent intoxication.Several compounds, notably (E)-1-(2-hydroxyethyl)-(1-naphthylvinyl)pyridinium bromide (3), (E)-1-methyl-4-(1-naphthylvinyl)-1,2,3,6-tetrahydropyridine hydrochloride (22), and (E)-1-methyl-4-(1-naphthylvinyl)piperidine hydrochloride (23), were found to afford significant protection against sarin in the mouse and against soman in the giunea pig.However, protection was apparently not related to CAT inhibition.Compound 23, our most effective compound in protecting against nerve agent, was without CAT inhibitory activity.Compound 22, which proved to be a potent CAT inhibitor, most likely owed this activity to being dehydrogenated back to the pyridinium quaternary salt by oxidative enzymes.Several of the (naphthylvinyl)pyridine quaternary salts, but not their tertiary amine analogues, were found to be effective in slowing the rate of aging of soman-inhibited acetylcholinesterase.Ability to slow the rate of aging was enhanced by introduction of methoxy substituents on the aryl moiety whereas the aging rate was actually accelerated by chloro substituents.To date, our most effective compound in slowing the rate of aging, (E)-4-pyridine methochloride (6), did not provide significant protection against soman in the mouse.

Anti-hypertensive piperidine compounds

Novel compounds of the formula: STR1 are described wherein Z is a bicyclic aryl group containing between 9 and 10 ring atoms, up to two of which may be nitrogen and up to one of which may be oxygen or sulfur; A is an ethenyl group which may be lower-alkyl-substituted; and R and R' each represent H or an aliphatic group of 1-4 carbon atoms; or a pharmaceutically acceptable acid addition salt thereof.