Asymmetric synthesis of (+)-preussin from N-sulfinyl δ-amino β-ketoesters
The efficient asymmetric synthesis of the antifungal pyrrolidine alkaloid (+)-preussin (2) was accomplished via the stereoselective reduction of a 5-substituted 3-oxo proline. The oxo proline was prepared from an N-sulfinyl δ-amino β-ketoester, a sulfinimine derived polyfunctionalized chiral building block.
Davis, Franklin A.,Deng, Jianghe
p. 5111 - 5115
(2007/10/03)
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