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CAS

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72141-57-2

Losulazine is a pharmaceutical compound with hypotensive properties, specifically designed as a novel peripheral sympatholytic agent. It functions by inhibiting the reuptake of norepinephrine, leading to a decrease in blood pressure. This makes it a valuable drug for the treatment of hypertension.

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  • [4-(4-fluorophenyl)sulfonylpiperazin-1-yl]-[4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl]methanone

    Cas No: 72141-57-2

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  • 72141-57-2 Structure

  • Basic information

    1. Product Name: Losulazine
    2. Synonyms: Losulazine;1-[(4-Fluorophenyl)sulfonyl]-4-[4-[[7-(trifluoromethyl)quinolin-4-yl]amino]benzoyl]piperazine
    3. CAS NO:72141-57-2
    4. Molecular Formula: C27H22F4N4O3S
    5. Molecular Weight: 558.55
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 72141-57-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 695.7°C at 760 mmHg
    3. Flash Point: 374.5°C
    4. Appearance: /
    5. Density: 1.454g/cm3
    6. Vapor Pressure: 3.35E-19mmHg at 25°C
    7. Refractive Index: 1.638
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: Losulazine(CAS DataBase Reference)
    11. NIST Chemistry Reference: Losulazine(72141-57-2)
    12. EPA Substance Registry System: Losulazine(72141-57-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 72141-57-2(Hazardous Substances Data)

72141-57-2 Usage

Uses

Used in Pharmaceutical Industry:
Losulazine is used as an antihypertensive agent for the treatment of high blood pressure. Its mechanism of action involves the inhibition of norepinephrine reuptake, which results in a reduction of blood pressure and provides relief from hypertension-related symptoms.
Used in the Preparation of 7-(Trifluoromethyl)-4-aminoquinoline Hypotensives:
Losulazine is utilized in the synthesis of 7-(Trifluoromethyl)-4-aminoquinoline derivatives, which are also hypotensive agents. These novel compounds exhibit peripheral sympatholytic activity, making them potential candidates for the development of new antihypertensive medications.

Check Digit Verification of cas no

The CAS Registry Mumber 72141-57-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,1,4 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 72141-57:
(7*7)+(6*2)+(5*1)+(4*4)+(3*1)+(2*5)+(1*7)=102
102 % 10 = 2
So 72141-57-2 is a valid CAS Registry Number.
InChI:InChI=1/C27H22F4N4O3S/c28-20-4-8-22(9-5-20)39(37,38)35-15-13-34(14-16-35)26(36)18-1-6-21(7-2-18)33-24-11-12-32-25-17-19(27(29,30)31)3-10-23(24)25/h1-12,17H,13-16H2,(H,32,33)

72141-57-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name [4-(4-fluorophenyl)sulfonylpiperazin-1-yl]-[4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl]methanone

1.2 Other means of identification

Product number -
Other names Losulazina

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:72141-57-2 SDS

72141-57-2Downstream Products

72141-57-2Relevant articles and documents

7-(Triflluoromethyl)-4-aminoquinoline Hypotensives: Novel Peripheral Sympatholytics

McCall, John M.,TenBrink, R. E.,Kamdar, Bharat V.,Skaletzky, Louis L.,Perricone, Salvatore C.,et al.

, p. 133 - 137 (2007/10/02)

A family of 7-(trifluoromethyl)-4-aminoquinolines that are hypotensive agents and that act by a novel sympatholytic mechanism is described.Structure-activity relationships in this series have been elucidated.Some of the more potent hypotensives were evalu

Antihypertensive 4-aminoquinolines

-

, (2008/06/13)

Antihypertensive compounds of the formula ll STR1 wherein X is chloro or trifluoromethyl; wherein R is an aromatic heterocyclic radical selected from the group consisting of triazinyl, pyrazinyl, pyridinyl, pyrimidinyl or the above radicals substituted by

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