723-69-3

Basic information

• Product Name: 2-(4-FLUOROPHENYL)-2-PHENYLACETIC ACID
• Synonyms: 2-(4-FLUOROPHENYL)-2-PHENYLACETIC ACID;(4-Fluoro-phenyl)-phenyl-acetic acid
• CAS NO: 723-69-3
• Molecular Formula: C₁₄H₁₁FO₂
• Molecular Weight: 230.23
• Mol File: 723-69-3.mol

Chemical Properties

• Melting Point: 104-106 °C
• Boiling Point: 346.2 °C at 760 mmHg
• Flash Point: 163.2 °C
• Appearance: /
• Density: 1.244 g/cm³
• Vapor Pressure: 2.22E-05mmHg at 25°C
• Refractive Index: 1.582
• PKA: 4.73±0.10(Predicted)
• CAS DataBase Reference: 2-(4-FLUOROPHENYL)-2-PHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROPHENYL)-2-PHENYLACETIC ACID(723-69-3)
• EPA Substance Registry System: 2-(4-FLUOROPHENYL)-2-PHENYLACETIC ACID(723-69-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 723-69-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Fluorophenyl)-2-phenylacetic acid is used as a key intermediate in the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs) for its role in the production of medications like flurbiprofen. It is valued for its contribution to the development of drugs that provide relief from pain, inflammation, and fever.
Used in Organic Chemistry:
In the field of organic chemistry, 2-(4-Fluorophenyl)-2-phenylacetic acid is utilized as a versatile building block for the creation of various organic compounds. Its structural properties make it suitable for use in the synthesis of a wide range of chemical entities, expanding its applications beyond pharmaceuticals to other areas of chemical research and development.

InChI:InChI=1/C14H11FO2/c15-12-8-6-11(7-9-12)13(14(16)17)10-4-2-1-3-5-10/h1-9,13H,(H,16,17)

Upstream product

• 103-82-2 phenylacetic acid 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 124-38-9 carbon dioxide 

Relevant articles and documents

Visible-Light-Driven External-Reductant-Free Cross-Electrophile Couplings of Tetraalkyl Ammonium Salts

Cross-electrophile couplings between two electrophiles are powerful and economic methods to generate C-C bonds in the presence of stoichiometric external reductants. Herein, we report a novel strategy to realize the first external-reductant-free cross-electrophile coupling via visible-light photoredox catalysis. A variety of tetraalkyl ammonium salts, bearing primary, secondary, and tertiary C-N bonds, undergo selective couplings with aldehydes/ketone and CO2. Notably, the in situ generated byproduct, trimethylamine, is efficiently utilized as the electron donor. Moreover, this protocol exhibits mild reaction conditions, low catalyst loading, broad substrate scope, good functional group tolerance, and facile scalability. Mechanistic studies indicate that benzyl radicals and anions might be generated as the key intermediates via photocatalysis, providing a new direction for cross-electrophile couplings.

Palladium-Catalyzed ?±-Arylation of Aryl Acetic Acid Derivatives via Dienolate Intermediates with Aryl Chlorides and Bromides

To date, examples of ?±-arylation of carboxylic acids remain scarce. Using a deprotonative cross-coupling process (DCCP), a method for palladium-catalyzed ?3-arylation of aryl acetic acids with aryl halides has been developed. This protocol is applicable to a wide range of aryl bromides and chlorides. A procedure for the palladium-catalyzed ?±-arylation of styryl acetic acids is also described.