Synthesis of Syn and Anti Isomers 6-methyl>-1--1H-benzimidazol-2-amine. Inhibitors of Rhinovirus Multiplication
The synthesis and antirhinovirus activity of syn and anti isomers of 6-methyl>-1--1H-benzimidazol-2-amine (4 and 5) are reported.The structural assignements of 4 and 5 are based upon 13C NMR spectra of both isomers and also X-ray analysis of 5.The anti-isomer 5 was more potent than the syn-isomer 4 when compared as an inhibitor of rhinovirus multiplication in vitro.Both isomers inhibited multiplication of 15 differrent serotypes of rhinovirus.
Wikel, J. H.,Paget, C. J.,DeLong, D. C.,Nelson, J. D.,Wu, C. Y. E.,et al.
p. 368 - 372
(2007/10/02)
Separation of syn and anti oximes of 1-sulfonyl-2-aminobenzimidazoles
Syn and anti oximes of 1-sulfonyl-2-aminobenzimidazoles are separated by selective crystallization.
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(2008/06/13)
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