72301-78-1

Basic information

• Product Name: Viroxime
• Synonyms: Viroxime;6-[[(Z)-Hydroxyimino]phenylmethyl]-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine;(1Z)-[2-AMino-1-[(1-Methylethyl)sulfonyl]-1H-benziMidazol-6-yl]phenylMethanone OxiMe
• CAS NO: 72301-78-1
• Molecular Formula: C₁₇H₁₈N₄O₃S
• Molecular Weight: 358.41
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 72301-78-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 607.2°C at 760 mmHg
• Flash Point: 321°C
• Appearance: /
• Density: 1.41g/cm³
• Vapor Pressure: 1.35E-15mmHg at 25°C
• Refractive Index: 1.676
• CAS DataBase Reference: Viroxime(CAS DataBase Reference)
• NIST Chemistry Reference: Viroxime(72301-78-1)
• EPA Substance Registry System: Viroxime(72301-78-1)

Safety Data

• Hazardous Substances Data: 72301-78-1(Hazardous Substances Data)

Usage

Description

Viroxime, also known as Zinviroxime, is the (Z)-isomer of Enviroxime (E559600). It is a benzimidazole derivative that possesses antiviral properties, specifically targeting the inhibition of rhinovirus multiplication. This makes it a potential candidate for the development of antiviral treatments against various viral infections.

Uses

Used in Pharmaceutical Industry:
Viroxime is used as an antiviral agent for inhibiting the multiplication of rhinoviruses. This application is particularly relevant in the context of treating common cold and other respiratory infections caused by rhinoviruses. By targeting the viral replication process, Viroxime can help reduce the severity and duration of these infections, improving patient outcomes and reducing the spread of the virus.
Used in Research and Development:
In addition to its potential therapeutic applications, Viroxime can also be utilized in research settings to better understand the mechanisms of rhinovirus replication and the development of antiviral resistance. This knowledge can contribute to the design of more effective antiviral drugs and strategies for combating viral infections.

InChI:InChI=1/C17H18N4O3S/c1-11(2)25(23,24)21-15-10-13(8-9-14(15)19-17(21)18)16(20-22)12-6-4-3-5-7-12/h3-11,22H,1-2H3,(H2,18,19)/b20-16-

Upstream product

• 63197-61-5 1-isopropylsulfonyl-2-amino-6-benzoylbenzimidazole 

Relevant articles and documents

Synthesis of Syn and Anti Isomers 6-methyl>-1--1H-benzimidazol-2-amine. Inhibitors of Rhinovirus Multiplication

The synthesis and antirhinovirus activity of syn and anti isomers of 6-methyl>-1--1H-benzimidazol-2-amine (4 and 5) are reported.The structural assignements of 4 and 5 are based upon 13C NMR spectra of both isomers and also X-ray analysis of 5.The anti-isomer 5 was more potent than the syn-isomer 4 when compared as an inhibitor of rhinovirus multiplication in vitro.Both isomers inhibited multiplication of 15 differrent serotypes of rhinovirus.