723299-75-0

Basic information

• Product Name: 4-(5,6-DICHLORO-1H-BENZIMIDAZOL-2-YL)BENZONITRILE
• Synonyms: 4-(5,6-DICHLORO-1H-BENZIMIDAZOL-2-YL)BENZONITRILE
• CAS NO: 723299-75-0
• Molecular Formula: C₁₄H₇Cl₂N₃
• Molecular Weight: 0
• Mol File: 723299-75-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(5,6-DICHLORO-1H-BENZIMIDAZOL-2-YL)BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5,6-DICHLORO-1H-BENZIMIDAZOL-2-YL)BENZONITRILE(723299-75-0)
• EPA Substance Registry System: 4-(5,6-DICHLORO-1H-BENZIMIDAZOL-2-YL)BENZONITRILE(723299-75-0)

Safety Data

• Hazardous Substances Data: 723299-75-0(Hazardous Substances Data)

Upstream product

• 5348-42-5 4,5-Dichloro-1,2-phenylenediamine 
• 105-07-7 4-cyanobenzaldehyde 

Downstream Products

• 316810-07-8 4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzoic acid 

Relevant articles and documents

Solid Phase Synthesis of Biologically active Benzimidazole Derivatives Catalysed by CH3S03H-Si02 under Solvent free Condition

A simple an expeditious method was established for the synthesis of 2-Substituted-1H-Benzimidazole derivatives at 90°C using o-phenylenediamine and different aldehydes. It has been found that a mixture of Methanesulphonic acid-Si02to be an effective catal

Vanadyl Acetylacetonate-Copper (II) Trifluoro Methane Sulfonate Catalyzed Eco-friendly Synthesis of Substituted Benzimidazoles in Aqueous Media

Various substituted benzimidazoles have been successfully synthesized in aqueous medium by developing VO(acac)2–Cu(OTf)2 catalytic system. A green synthetic protocol has been created in presence of water and cetyltrimethyl ammonium bromide (CTAB) system in an organic solvent free condition. This chemoselective cyclocondensation cumoxidation process occurred in aqueous media. In this suitable method easily synthesized 2-Substituted benzimidazoles with good yields and no 1,2-disubstituted by-products were noticed. Excellent yields, environmentally benign and mild reaction condition, easy purification of the desired products are the main attractive features of this newly devised method.

HETEROARYL RHEB INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same. Compositions comprising a compound of this invention or a pharmaceutically acceptable derivative thereof and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The amount of the compound in compositions of this invention is such that it is effective to measurably inhibit Rheb, in a biological sample or in a patient.

PEG-mediated catalyst-free expeditious synthesis of 2-substituted benzimidazoles and bis-benzimidazoles under solvent-less conditions

A wide variety of 2-substituted benzimidazoles and bis-benzimidazoles were synthesized in high yields by PEG-mediated catalyst-free synthesis under solvent-less conditions. The products were directly recrystallized from hot methanol. The reaction occurred giving excellent yields with low as well as high molecular weight PEGs.