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724424-43-5

(R)-2-CHLORO-5-(4-(HYDROXY(METHOXY)METHYL)-3,5-DIOXO-4,5-DIHYDRO-1,2,4-TRIAZIN-2(3H)-YL)-N-((1-HYDROXYCYCLOHEPTYL)METHYL)BENZAMIDE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 2-chloro-N-[(1-hydroxycycloheptyl)methyl]-5-[4-[(2R)-2-hydroxy-3-methoxypropyl]-3,5-dioxo-1,2,4-triazin-2-yl]benzamide

    Cas No: 724424-43-5

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  • (R)-2-CHLORO-5-(4-(HYDROXY(METHOXY)METHYL)-3,5-DIOXO-4,5-DIHYDRO-1,2,4-TRIAZIN-2(3H)-YL)-N-((1-HYDROXYCYCLOHEPTYL)METHYL)BENZAMIDE

    Cas No: 724424-43-5

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  • (R)-2-CHLORO-5-(4-(HYDROXY(METHOXY)METHYL)-3,5-DIOXO-4,5-DIHYDRO-1,2,4-TRIAZIN-2(3H)-YL)-N-((1-HYDROXYCYCLOHEPTYL)METHYL)BENZAMIDE

    Cas No: 724424-43-5

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  • 724424-43-5 Structure

  • Basic information

    1. Product Name: (R)-2-CHLORO-5-(4-(HYDROXY(METHOXY)METHYL)-3,5-DIOXO-4,5-DIHYDRO-1,2,4-TRIAZIN-2(3H)-YL)-N-((1-HYDROXYCYCLOHEPTYL)METHYL)BENZAMIDE
    2. Synonyms: (R)-2-CHLORO-5-(4-(HYDROXY(METHOXY)METHYL)-3,5-DIOXO-4,5-DIHYDRO-1,2,4-TRIAZIN-2(3H)-YL)-N-((1-HYDROXYCYCLOHEPTYL)METHYL)BENZAMIDE;A P2X7 receptor antagonist;CE 224535;PF-04905428
    3. CAS NO:724424-43-5
    4. Molecular Formula: C20H25ClN4O6
    5. Molecular Weight: 480.94
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 724424-43-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.47g/cm3
    6. Refractive Index: 1.649
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 13.48±0.20(Predicted)
    10. CAS DataBase Reference: (R)-2-CHLORO-5-(4-(HYDROXY(METHOXY)METHYL)-3,5-DIOXO-4,5-DIHYDRO-1,2,4-TRIAZIN-2(3H)-YL)-N-((1-HYDROXYCYCLOHEPTYL)METHYL)BENZAMIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: (R)-2-CHLORO-5-(4-(HYDROXY(METHOXY)METHYL)-3,5-DIOXO-4,5-DIHYDRO-1,2,4-TRIAZIN-2(3H)-YL)-N-((1-HYDROXYCYCLOHEPTYL)METHYL)BENZAMIDE(724424-43-5)
    12. EPA Substance Registry System: (R)-2-CHLORO-5-(4-(HYDROXY(METHOXY)METHYL)-3,5-DIOXO-4,5-DIHYDRO-1,2,4-TRIAZIN-2(3H)-YL)-N-((1-HYDROXYCYCLOHEPTYL)METHYL)BENZAMIDE(724424-43-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 724424-43-5(Hazardous Substances Data)

724424-43-5 Usage

Uses

CE-224535, is a selective P2X7 receptor antagonist.

Check Digit Verification of cas no

The CAS Registry Mumber 724424-43-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,2,4,4,2 and 4 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 724424-43:
(8*7)+(7*2)+(6*4)+(5*4)+(4*2)+(3*4)+(2*4)+(1*3)=145
145 % 10 = 5
So 724424-43-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H25ClN4O6/c1-31-19(29)24-16(26)11-23-25(18(24)28)13-6-7-15(21)14(10-13)17(27)22-12-20(30)8-4-2-3-5-9-20/h6-7,10-11,19,29-30H,2-5,8-9,12H2,1H3,(H,22,27)/t19-/m1/s1

724424-43-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-N-[(1-hydroxycycloheptyl)methyl]-5-[4-[(2R)-2-hydroxy-3-methoxypropyl]-3,5-dioxo-1,2,4-triazin-2-yl]benzamide

1.2 Other means of identification

Product number -
Other names UNII-T8B02RAU3C

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:724424-43-5 SDS

724424-43-5Downstream Products

724424-43-5Relevant articles and documents

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535

Duplantier, Allen J.,Dombroski, Mark A.,Subramanyam, Chakrapani,Beaulieu, Aimee M.,Chang, Shang-Poa,Gabel, Christopher A.,Jordan, Crystal,Kalgutkar, Amit S.,Kraus, Kenneth G.,Labasi, Jeff M.,Mussari, Christopher,Perregaux, David G.,Shepard, Rick,Taylor, Timothy J.,Trevena, Kristen A.,Whitney-Pickett, Carrie,Yoon, Kwansik

, p. 3708 - 3711 (2011/07/31)

High throughput screening (HTS) of our compound file provided an attractive lead compound with modest P2X7 receptor antagonist potency and high selectivity against a panel of receptors and channels, but also with high human plasma protein bindi

Combination therapies utilizing benzamide inhibitors of the P2X7 receptor

-

Page/Page column 41; 42, (2010/02/15)

This invention provides methods of treatment of IL-1 mediated diseases comprising administering a pharmaceutically effective amount of a pharmaceutical agent selected from the group of sulfasalazine, a statin, a glucocorticoid agent, an inhibitor of p38 k

Methods for preparing P2X7 inhibitors

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Page/Page column 16, (2010/02/15)

The present invention relates to the methods for preparing compounds of the formula I: or the pharmaceutically acceptable salts thereof, wherein R1, R2, R4, R10, and R11 have any of the values defined

Methods for preparing P2X7 inhibitors

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Page/Page column 26-27, (2008/06/13)

The present invention relates to methods of preparing compounds of formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R4, and R7 have any of the values as defined in the specification. The

3-(3,5-DIOXO-4,5-DIHYDRO-3H-(1,2,4)TRIAZIN-2-YL)-BENZAMIDE DERIVATIVES AS P2X7-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES

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Page/Page column 60, (2008/06/13)

The present invention provides benzamide inhibitors of the P2X7 receptor of the formula (I), wherein R1 and R2 are as defined in claim 1. R3 is a nitrogen linked (C1-C10) heterocyclyl of fo

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