64491-70-9

Basic information

• Product Name: (R)-(-)-Methyl glycidyl ether
• Synonyms: (R)-(-)-METHYL GLYCIDYL ETHER;(R)-METHYL GLYCIDYL ETHER;(R)-(-)-GLYCIDYL METHYL ETHER;(R)-GLYCIDYL METHYL ETHER;(R)-1-METHYLOXY-2,3-EPOXYPROPANE;(R)-1-METHOXY-2,3-EPOXYPROPANE;(R)-2-(METHOXYMETHYL)OXIRANE;R(-)-2-(METHOXYMETHYL)OXIRANE
• CAS NO: 64491-70-9
• Molecular Formula: C₄H₈O₂
• Molecular Weight: 88.11
• Product Categories: chiral;Chiral Building Blocks;Glycidyl Compounds, etc. (Chiral);Oxiranes;Simple 3-Membered Ring Compounds;Synthetic Organic Chemistry;Chiral Compound
• Mol File: 64491-70-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 110-111 °C(lit.)
• Flash Point: 68 °F
• Appearance: Colorless to light yellow liquid
• Density: 0.982 g/mL at 25 °C(lit.)
• Vapor Pressure: 21.6mmHg at 25°C
• Refractive Index: n20/D 1.406(lit.)
• Storage Temp.: Flammables area
• Water Solubility: soluble
• BRN: 102505
• CAS DataBase Reference: (R)-(-)-Methyl glycidyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-Methyl glycidyl ether(64491-70-9)
• EPA Substance Registry System: (R)-(-)-Methyl glycidyl ether(64491-70-9)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-19-36/37/38
• Safety Statements: 16-26-37/39
• RIDADR: UN 3271 3/PG 2
• WGK Germany: 3
• F: 3-10
• HazardClass: 3/6.1
• PackingGroup: II
• Hazardous Substances Data: 64491-70-9(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liqui

InChI:InChI=1/C4H8O2/c1-5-2-4-3-6-4/h4H,2-3H2,1H3/t4-/m0/s1

Upstream product

• 930-37-0 glycidyl methyl ether 

Downstream Products

• 723242-85-1 2-chloro-N-(1-hydroxy-cycloheptylmethyl)-5-[4-(2-hydroxy-3-methoxy-propyl)-3-methyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]benzamide 
• 1258856-42-6 methyl (2R)-3-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]-2-hydroxypropanoate 
• 1323394-00-8 (R)-9-[(3-methoxy-2-hydroxy)propyl]-6-O-benzylguanine 
• 73422-88-5 1-phenylmethyl-3-methoxy-1,2-propanediol 
• 241139-32-2 (R)-5-methoxymethyloxazolidin-2-one 
• 95120-45-9 (2R)-3-methoxy-1-(2-nitroimidazol-1-yl)-2-propanol 
• 1174289-21-4 (R)-1-amino-3-methoxypropan-2-ol 
• 1085543-96-9 (2S)-1-amino-3-methoxy-2-propanol 

Relevant articles and documents

Enantioselective Resolution Copolymerization of Racemic Epoxides and Anhydrides: Efficient Approach for Stereoregular Polyesters and Chiral Epoxides

Herein we report an efficient strategy for preparing isotactic polyesters and chiral epoxides via enantioselective resolution copolymerization of racemic terminal epoxides with anhydrides, mediated by enantiopure bimetallic complexes in conjunction with a nucleophilic cocatalyst. The chirality of both the axial linker and the diamine backbones of the ligand are responsible for the chiral induction of this kinetic resolution copolymerization process. The catalyst systems exhibit exceptional levels of enantioselectivity with a kinetic resolution coefficient exceeding 300 for various racemic epoxides, affording highly isotactic copolymers (selectivity factors of more than 300) with a completely alternating structure and low polydispersity index. Most of the produced isotactic polyesters are typical semicrystalline materials with melting temperatures in the range from 77 to 160 °C.

A new dinuclear chiral salen complexes for asymmetric ring opening and closing reactions: Synthesis of valuable chiral intermediates

A new dinuclear chiral Co(salen) complexes bearing group 13 metals have been synthesized and characterized. The easily prepared complexes exhibited very high catalytic reactivity and enantioselectivity for the asymmetric ring opening of epoxides with H2O, chloride ions and carboxylic acids and consequently provide enantiomerically enriched terminal epoxides (>99% ee). It also catalyzes the asymmetric cyclization of ring opened product, to prepare optically pure terminal epoxides in one step. The homogeneous dinuclear chiral Co(salen) have been covalently immobilized on MCM-41. The potential benefits of heterogenization include facilitation of catalyst separation and recyclability requiring very simple techniques. The system described is very efficient.