Convenient Synthesis of 10-Deazaaminopterin via a Pteridine Ylide
10-Deazaaminopterin, a potential antitumor agent now undergoing clinical trials, has been synthesized by a new approach involving the Wittig reaction.The ylide obtained by reaction of 6-(bromomethyl)-2,4-pteridinediamine with triphenylphosphine in Me2NAc,
Piper, James R.,Montgomery, John A.
p. 320 - 321
(2007/10/02)
Process for the preparation of 10-deazaaminopterin and related compounds
There is disclosed an improved process for the preparation of 10-deazaaminopterin and related compounds. In accordance with this process, 6-(bromomethyl)-2,4-pteridinediamine hydrobromide is reacted with triphenylphosphine to form a phosphonium salt which
-
(2008/06/13)
More Articles about upstream products of 72469-06-8