72469-06-8Relevant academic research and scientific papers
Convenient Synthesis of 10-Deazaaminopterin via a Pteridine Ylide
Piper, James R.,Montgomery, John A.
, p. 320 - 321 (2007/10/02)
10-Deazaaminopterin, a potential antitumor agent now undergoing clinical trials, has been synthesized by a new approach involving the Wittig reaction.The ylide obtained by reaction of 6-(bromomethyl)-2,4-pteridinediamine with triphenylphosphine in Me2NAc,
Process for the preparation of 10-deazaaminopterin and related compounds
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, (2008/06/13)
There is disclosed an improved process for the preparation of 10-deazaaminopterin and related compounds. In accordance with this process, 6-(bromomethyl)-2,4-pteridinediamine hydrobromide is reacted with triphenylphosphine to form a phosphonium salt which
