724744-76-7

Basic information

• Product Name: 1H-Pyrrole-3-carboxylicacid,1-ethyl-2-methyl-5-phenyl-(9CI)
• Synonyms: 1H-Pyrrole-3-carboxylicacid,1-ethyl-2-methyl-5-phenyl-(9CI);1-Ethyl-2-methyl-5-phenyl-1H-pyrrole-3-carboxylic acid
• CAS NO: 724744-76-7
• Molecular Formula: C₁₄H₁₅NO₂
• Molecular Weight: 229.2744
• Product Categories: ETHYL
• Mol File: 724744-76-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrole-3-carboxylicacid,1-ethyl-2-methyl-5-phenyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-carboxylicacid,1-ethyl-2-methyl-5-phenyl-(9CI)(724744-76-7)
• EPA Substance Registry System: 1H-Pyrrole-3-carboxylicacid,1-ethyl-2-methyl-5-phenyl-(9CI)(724744-76-7)

Safety Data

• Hazardous Substances Data: 724744-76-7(Hazardous Substances Data)

Upstream product

• 879329-60-9 ethyl 1-ethyl-2-methyl-5-phenyl-1H-pyrrole-3-carboxylate 

Downstream Products

• 1220830-70-5 N-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)-1-ethyl-2-methyl-5-phenyl-1H-pyrrole-3-carboxamide 

Relevant articles and documents

ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS

The present invention relates to novel arylpiperazine-containing pyrrole 3-carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof which is useful for preventing or treating depressive disorders. The present invention also provides a method for preparing the arylpiperazine-containing pyrrole 3-carboxamide derivatives or the pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and a method for preventing or treating depressive disorders.

Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant

Arylpiperzine-containing pyrrole 3-carboxamide derivatives were synthesized and evaluated as novel antidepressant compounds. The various analogues were efficiently prepared and bio-assayed for binding to 5-HT2A, 5-HT2C receptor, and

Further optimization of novel pyrrole 3-carboxamides for targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant

In the continuing search for novel compounds targeting serotonin 5-HT 2A, 5-HT2C, and serotonin transporter, new arylpiperazine-containing pyrrole 3-carboxamide derivatives were synthesized and evaluated. Based on the lead reported previously, structural modifications regarding N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)-1,2-dimethyl-5- phenyl-1H-pyrrole-3-carboxamide 5, were accomplished for improvements in not only binding affinity against serotonin receptors and transporter, but also in hERG channel inhibition. Along the line, both the forced swimming tests and spontaneous locomotor activity tests were performed to distinguish between antidepressant activity and false positive results. As potential antidepressant agents, both 2,4-dimethyl-5-phenyl-1H-pyrrole-3-carboxamide and 5-tert-butyl-2-methyl-1H-pyrrole-3-carboxamide derivatives exhibited favorable in vitro and in vivo activities, warranting further investigation around these scaffolds.