879329-60-9Relevant academic research and scientific papers
Sonochemically assisted synthesis of N-substituted pyrroles catalyzed by ZnO nanoparticles under solvent-free conditions
Shahvelayati, Ashraf S,Sabbaghan, Maryam,Banihashem, Solmaz
, p. 1123 - 1129 (2017/05/10)
Abstract: An efficient and rapid synthesis of 1,2,3,5-tetrasubstituted pyrrole derivatives from a one-pot multicomponent reaction of amines, 1,3-dicarbonyl compounds, and α-haloketones in the presence of ZnO nanoparticles catalyst under ultrasonic irradiation and solvent-free conditions is described. Graphical abstract: [Figure not available: see fulltext.].
Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant
Kang, Suk Youn,Park, Eun-Jung,Park, Woo-Kyu,Kim, Hyun Jung,Jeong, Daeyoung,Jung, Myung Eun,Song, Kwang-Seop,Lee, Suk Ho,Seo, Hee Jeong,Kim, Min Ju,Lee, MinWoo,Han, Ho-Kyun,Son, Eun-Jung,Pae, Ae Nim,Kim, Jeongmin,Lee, Jinhwa
scheme or table, p. 1705 - 1711 (2010/06/19)
Arylpiperzine-containing pyrrole 3-carboxamide derivatives were synthesized and evaluated as novel antidepressant compounds. The various analogues were efficiently prepared and bio-assayed for binding to 5-HT2A, 5-HT2C receptor, and
Further optimization of novel pyrrole 3-carboxamides for targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant
Kang, Suk Youn,Park, Eun-Jung,Park, Woo-Kyu,Kim, Hyun Jung,Choi, Gildon,Jung, Myung Eun,Seo, Hee Jeong,Kim, Min Ju,Pae, Ae Nim,Kim, Jeongmin,Lee, Jinhwa
experimental part, p. 6156 - 6169 (2010/09/14)
In the continuing search for novel compounds targeting serotonin 5-HT 2A, 5-HT2C, and serotonin transporter, new arylpiperazine-containing pyrrole 3-carboxamide derivatives were synthesized and evaluated. Based on the lead reported previously, structural modifications regarding N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)-1,2-dimethyl-5- phenyl-1H-pyrrole-3-carboxamide 5, were accomplished for improvements in not only binding affinity against serotonin receptors and transporter, but also in hERG channel inhibition. Along the line, both the forced swimming tests and spontaneous locomotor activity tests were performed to distinguish between antidepressant activity and false positive results. As potential antidepressant agents, both 2,4-dimethyl-5-phenyl-1H-pyrrole-3-carboxamide and 5-tert-butyl-2-methyl-1H-pyrrole-3-carboxamide derivatives exhibited favorable in vitro and in vivo activities, warranting further investigation around these scaffolds.
