cas 724788-64-1, ethyl 4-broMo-6-Methoxy-1,5-naphthyridine-3-carboxylate

Articles about 724788-64-1Total 15 be found

ANTIBACTERIAL COMPOUNDS HAVING BROAD SPECTRUM OF ACTIVITY
The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.
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(2016/07/05)

Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents
Bacterial resistance is eroding the clinical utility of existing antibiotics necessitating the discovery of new agents. Bacterial type II topoisomerase is a clinically validated, highly effective, and proven drug target. This target is amenable to inhibit
Singh, Sheo B.,Kaelin, David E.,Wu, Jin,Miesel, Lynn,Tan, Christopher M.,Meinke, Peter T.,Olsen, David,Lagrutta, Armando,Bradley, Prudence,Lu, Jun,Patel, Sangita,Rickert, Keith W.,Smith, Robert F.,Soisson, Stephen,Wei, Changqing,Fukuda, Hideyuki,Kishii, Ryuta,Takei, Masaya,Fukuda, Yasumichi
p. 609 - 614
(2014/06/09)

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases
We have identified a series of amino-piperidine antibacterials with a good broad spectrum potency. We report the investigation of various subunits in this series and advanced studies on compound 8. Compound 8 possesses good pharmacokinetics, broad spectrum antibacterial activity and demonstrates oral efficacy in a rat lung infection model.
Miles, Timothy J.,Axten, Jeffrey M.,Barfoot, Christopher,Brooks, Gerald,Brown, Pamela,Chen, Dongzhao,Dabbs, Steven,Davies, David T.,Downie, David L.,Eyrisch, Susanne,Gallagher, Timothy,Giordano, Ilaria,Gwynn, Michael N.,Hennessy, Alan,Hoover, Jennifer,Huang, Jianzhong,Jones, Graham,Markwell, Roger,Miller, William H.,Minthorn, Elizabeth A.,Rittenhouse, Stephen,Seefeld, Mark,Pearson, Neil
p. 7489 - 7495
(2012/02/04)

Antibacterial Agents
Naphthalene, quinoline, quinoaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
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Page/Page column 9

(2008/12/07)

ANTIBACTERIAL AGENTS
Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
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Page/Page column 21; 25; 26

(2010/11/25)

ANTIBACTERIAL AGENTS
Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment bacterial infections in mammals, particularly humans, are disclosed herein.
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Page/Page column 24

(2010/10/19)

ANTIBACTERIAL AGENTS
Naphthyridine and related derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
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Page/Page column 18

(2008/06/13)

ANTIBACTERIAL AGENTS
Naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
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Page/Page column 21-22

(2008/06/13)

ANTIBACTERIAL AGENTS
Naphthyridine and quinoline derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
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Page/Page column 15

(2008/06/13)

ANTIBACTERIAL AGENTS
Naphthyridine and related derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
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Page/Page column 19

(2008/06/13)

ANTIBACTERIAL AGENTS
Naphthyridine and related derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
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Page/Page column 19

(2008/06/13)

ANTIBACTERIAL AGENTS
Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
-
Page/Page column 64; 67

(2010/02/15)

ANTIBACTERIAL AGENTS
Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
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Page/Page column 31; 48

(2010/10/19)

ANTIBACTERIAL AGENTS
Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
-
Page/Page column 21

(2010/10/20)

ANTIBACTERIAL AGENTS
Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
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Page/Page column 26; 40

(2010/10/20)