Nickel-catalysed selective N-arylation or N,N′-diarylation of secondary diamines
The selective synthesis of N-aryl or N,N′-diaryl piperazines and trimethylene(bis)piperidines from the corresponding diamines and aryl chlorides using a catalyst combination of Ni(0) associated to 2,2′-bipyridine is described. The Ni/2,2′-bipyridine catalyst is also effective for the sequential arylation of piperazine. The preparation of novel and unsymmetrical 1,4-diaryl piperazines is reported.
Brenner, Eric,Schneider, Rapha?l,Fort, Yves
p. 6913 - 6924
(2007/10/03)
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