- Syntheses of 2-sulfamoylmethylbenzoxazole derivatives and determination of their anticonvulsant activities
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Some 2-sulfamoylmethylbenzoxazole derivatives were synthesized from 2-bromomethylbenzoxazole by reaction with sodium bisulfite, followed by chlorination and amination. Among them, 2-sulfamoylmethylbenzoxazole showed the strongest anticonvulsant activity, which was compared with that of 3-sulfamoylmethyl-1,2-benzisoxazole (I).
- Uno,Kurokawa,Masuda
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p. 2359 - 2361
(2007/10/02)
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- Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
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Methane-sulfonamide derivatives of the formula: STR1 wherein R1 is hydrogen or a halogen atom, R2 and R3 are the same or different and are each hydrogen or a straight or branched alkyl having 1 to 3 carbon atoms, and one of X and Y is a carbon atom and another is a nitrogen atom, provided that the group: --CH2 SO2 NR2 R3 is bonded to the carbon atom of either of X and Y, and an alkali metal salt thereof, and a process for the preparation of said methane-sulfonamide derivatives. Said compounds have an excellent anticonvulsant activity and are useful as anticonvulsants for controlling convulsions and seizures in patients with epilepsy.
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