73387-46-9

Basic information

• Product Name: 3-(4-BROMOPHENYL)-1H-PYRAZOLE, 97%
• Synonyms: 3-(4-Bromophenyl)-1H-pyrazole;1-Bromo-4-(1H-pyrazol-3-yl)benzene;3-(4-BroMophenyl)-1H-pyrazol;3-(4-bromophenyl)-2H-pyrazole;676292_ALDRICH;ZINC04293887
• CAS NO: 73387-46-9
• Molecular Formula: C₉H₇BrN₂
• Molecular Weight: 223.07
• Product Categories: Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrazoles;PyrazolesHeterocyclic Building Blocks;Building Blocks;C9;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 73387-46-9.mol

Chemical Properties

• Melting Point: 132-136 °C
• Boiling Point: 388.9 °C at 760 mmHg
• Flash Point: 189 °C
• Appearance: /
• Density: 1.565
• Vapor Pressure: 6.66E-06mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: 2-8°C(protect from light)
• PKA: 12.80±0.10(Predicted)
• CAS DataBase Reference: 3-(4-BROMOPHENYL)-1H-PYRAZOLE, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-BROMOPHENYL)-1H-PYRAZOLE, 97%(73387-46-9)
• EPA Substance Registry System: 3-(4-BROMOPHENYL)-1H-PYRAZOLE, 97%(73387-46-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 73387-46-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Bromophenyl)-1H-pyrazole, 97% is used as a key intermediate for the synthesis of various pharmaceuticals, due to its reactivity and ability to form new compounds through nucleophilic substitutions.
Used in Organic Chemistry Research:
3-(4-Bromophenyl)-1H-pyrazole, 97% is used as a reagent in organic chemistry research, allowing for the exploration of new reactions and the development of novel organic compounds.
Used in Chemical Synthesis:
3-(4-Bromophenyl)-1H-pyrazole, 97% is used as a building block in the synthesis of complex organic molecules, leveraging its reactivity to create a wide range of chemical structures.

InChI:InChI=1/C9H7BrN2/c10-8-3-1-7(2-4-8)9-5-6-11-12-9/h1-6H,(H,11,12)

Upstream product

• 37614-58-7 3-(4-bromophenyl)prop-2-yn-1-ol 
• 4592-94-3 3-(4-bromophenyl)-3-oxopropanenitrile 
• 99-90-1 para-bromoacetophenone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 49678-04-8 4-bromocinnamaldeyde 
• 73387-60-7 (2E)-1-(4-bromophenyl)-3-(dimethylamino)prop-2-en-1-one 

Downstream Products

• 1199805-44-1 3-(4-bromophenyl)-1-ethyl-1H-pyrazole 
• 474707-80-7 3-(4-bromophenyl)-1-trityl-1H-pyrazole 
• 1124-14-7 1-bromo-4-cyclopropylbenzene 

Relevant articles and documents

Preparation method of pyrazole derivative (by machine translation)

The preparation method comprises the following steps: mixing an alkyne propyl alcohol derivative, a halogen source, an acid and a solvent, heating and reacting, and reacting to Meyer - Schuster generate the pyrazole derivative. Compared with the prior art, the preparation method disclosed by the invention has 91% the advantages of maximum yield, simple operation, mild conditions, high conversion rate, few byproducts and the like, and provides a brand-new synthetic method for construction of pyrazole compounds. (by machine translation)

Enaminone-Derived Pyrazoles with Antimicrobial Activity

A series of pyrazoles derived from the substituted enaminones were synthesized and were evaluated for antimicrobial activity. All the compounds were characterized by the spectral data and elemental analysis. The synthesized compounds were initially screen

Chemoselective Reduction of α-Cyano Carbonyl Compounds: Application to the Preparation of Heterocycles

β-Aminoacrylates are reactive intermediates that are useful building blocks in synthesis. General methods for their preparation typically afford α and β disubstitution patterns or β only. Molecules with only α-substituents (β-hydrogen) are much less well-known. A chemoselective reductive tautomerization of α-cyanoacetates, using DIBAL-H, has been developed to access these valuable synthons. α,β-Unsaturated cyanoacetates and α-cyanoketones can, also, be selectively reduced via this methodology. A series of heterocycles were prepared using these β-enamino carbonyl compounds.

NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A

The present invention relates to compounds of the formula I and their salts etc. which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders. wherein Y1 and Y2 are adjacent atoms in Het1, which are independently selected from the group consisting of carbon and nitrogen; k is 0, 1, 2 or 3; Het1 is a bivalent monocyclic 5- or 6-membered heteroaromatic radical, having 1, 2 or 3 heteroatoms or heteroatom moieties selected from O, S, N and N—Ra as ring members, or a bivalent fused bicyclic 8-, 9- or 10-membered heteroaromatic radical, having 1, 2, 3 or 4 heteroatoms or heteroatom moieties selected from O, S, N and N—Ra as ring members; Het2 is inter alia monocyclic 5- or 6-membered hetaryl, having 1, 2 or 3 heteroatoms or heteroatom moieties selected from O, S, N and N—R1a as ring members, Cyc is inter alia optionally substituted monocyclic 5- or 6-membered hetaryl or optionally substituted fused 8-, 9- or 10-membered bicyclic hetaryl; Ar is optionally substituted phenylene or optionally substituted bivalent 6-membered hetaryl; R is attached to a carbon atom of Het1 and inter alia-halogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, C1-C6-fluoroalkyl, C1-C6-fluoroalkoxy, C3-C6-cycloalkyl etc.

A simple and efficient synthesis of pyrazoles in water

A simple, highly efficient, and environmentally friendly method for the synthesis of substituted 1H-pyrazoles by one-pot condensation reaction of α,β-unsaturated carbonyl compounds with tosyl hydrazide in water was developed. The reaction system exhibited tolerance with various functional groups, Aromatic moiety with both electron-rich and electron-deficient substituents could give desired products in good to excellent yields.

PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH

The present invention is directed to certain imidazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and t