735315-15-8

Basic information

• Product Name: 3Ac-SL0101
• Synonyms: 3Ac-SL0101;4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2,3,4-tri-O-acetyl-6-deoxy-a-L-Mannopyranosyl)oxy]-;OFWDHNGVKNRLFY-LHZKXVGGSA-N
• CAS NO: 735315-15-8
• Molecular Formula: C₂₇H₂₆O₁₃
• Molecular Weight: 558.48754
• Mol File: 735315-15-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3Ac-SL0101(CAS DataBase Reference)
• NIST Chemistry Reference: 3Ac-SL0101(735315-15-8)
• EPA Substance Registry System: 3Ac-SL0101(735315-15-8)

Safety Data

• Hazardous Substances Data: 735315-15-8(Hazardous Substances Data)

Upstream product

• 910041-19-9 (2S,3R,4R,5S,6S)-2-((5,7-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-4-oxo-4H-chromen-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 865484-73-7 tert-butyl ((2S,6S)-6-methyl-5-oxo-5,6-dihydro-2H-pyran-2-yl) carbonate 
• 23405-70-1 5,7-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-hydroxy-4H-chromen-4-one 
• 916069-02-8 3-((2S,6S)-5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yloxy)-5,7-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-4H-chromen-4-one 
• 916069-03-9 3-((2S,5R,6S)-5,6-dihydro-5-hydroxy-6-methyl-2H-pyran-2-yloxy)-5,7-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-4H-chromen-4-one 
• 916069-04-0 5,7-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one 
• 1192-62-7 1-(2-furyl)-1-ethanone 
• 96333-59-4 5,7-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-4H-chromen-4-one 
• 480-41-1 5,7-Dihydroxy-2-(4-hydroxy-phenyl)-chroman-4-on 
• 247244-65-1 L-aculose 
• 4208-64-4 (S)-1-(2-furanyl)ethanol 
• 88607-79-8 (E)-1-(2,4-bis(benzyloxy)-6-hydroxyphenyl)-3-(4-(benzyloxy)phenyl)prop-2-en-1-one 
• 5158-64-5 2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl bromide 

Downstream Products

• 72165-31-2 Peracetylated-SL₀₁₀₁ 

Relevant articles and documents

INFLUENCE OF RHAMNOSE SUBSTITUENTS ON THE POTENCY OF SL0101, AN INHIBITOR OF THE SER/THR KINASE, RSK

The present invention provides compositions and methods useful for preparing and using analogs, derivatives, and modifications of kaempferols that have anti-neoplastic activity. More specifically, the compounds are analogs, derivatives, and modifications

Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK

We have previously reported the isolation of kaempferol 3-O-(3″,4″-di-O-acetyl-α-l-rhamnopyranoside) from Forsteronia refracta [Xu, Y.-M.; Smith, J. A.; Lannigan, D. A.; Hecht, S. M. Biorg. Med. Chem. 2006, 14, 3974-3977.]. This flavonoid glycoside, terme

De novo asymmetric syntheses of SL0101 and its analogues via a palladium-catalyzed glycosylation

(Chemical Equation Presented) The enantioselective syntheses of naturally occurring kaempferol glycoside SL0101 (1a) and its analogues 1b-e, as well as their enantiomers, have been achieved in 7-10 steps. The routes rely upon a diastereoselective palladium-catalyzed glycosylation, ketone reduction, and dihydroxylation to introduce the rhamno-stereochemistry. The asymmetry of the sugar moiety of these kaempferol glycosides was derived from Noyori reduction of an acylfuran. An acetyl group shift from an axial (C-2) to equatorial position (C-3) under basic conditions was also described.