480-41-1Relevant articles and documents
Synthesis, structural elucidation and antiradical activity of a copper (II) naringenin complex
Celiz, Gustavo,Suarez, Sebastián A.,Arias, Analía,Molina, José,Brondino, Carlos D.,Doctorovich, Fabio
, p. 595 - 610 (2019)
Coupling the extraction and derivatization of flavonoids to the Citrus processing industry is attractive from both the environmental and economic points of view. In the present work, the flavonoid naringin, obtained by “green” extraction with a water:ethanol mixture from waste grapefruit industry, was hydrolyzed to obtain naringenin. This flavonoid was used to synthesize the complex trans-di(aqua) bis(7-hydroxy-2-(4-hydroxyphenyl)-4-oxo-5-chromanolato) copper (II). This compound was characterized by spectroscopic techniques (UV/Vis, IR, Raman, NMR and EPR), and by thermal analysis (TG and DSC). Then, a monocrystal of the complex obtained by dissolution and recrystallization in DMF was analyzed by single crystal X-ray diffraction. This is the first report of the crystal structure of a Citrus flavonoid complex. Additionally, its antiradical activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) was determined and compared with that for naringenin, demonstrating that coordination to copper enhances the antiradicalar activity of naringenin. According to the Mulliken population analysis conducted, by copper favors the delocalization and stabilization of the produced radical, since it acts as an electronic density acceptor.
Sulfation of naringenin by Cunninghamella elegans
Ibrahim, Abdel-Rahim S.
, p. 209 - 212 (2000)
A new flavonoid sulfate, naringenin-7-sulfate, was obtained by fermentation of naringenin using the fungus Cunninghamella elegans NRRL 1392 in 23% yield. Structural elucidation of the metabolite was achieved using EIMS, UV, IR, 1D and 2D NMR spectroscopy beside acid and enzyme hydrolyses. (C) 2000 Elsevier Science Ltd.
GLUCOSYLATED FLAVONOIDS AND OTHER PHENOLIC COMPOUNDS FROM SORGHUM
Gujer, Rene,Magnolato, Daniele,Self, Ron
, p. 1431 - 1436 (1986)
The principal tannin constituents of sorghum are proanthocyanidins or condensed tannins.Analysis of the methanolic extract of a Hungarian sorghum (szegedi toerpe) containing 6percent catechin equivalents of tannins resulted in the separation and purification of 4 procyanidins having the basic formula epicatechin-(epicatechin)n-catechin and one procyanidin trimer corresponding to epicatechin-catechin-epicatechin.Apart from these procyanidins, the monomeric flavonoids eriodictyol 5-glucoside and (+)-taxifolin 7 glucoside together with their aglycones eriodictyol and taxifolin were found.Glucosylated dimeric and trimeric flavanoids with eriodictyol or eriodictyol 5-glucoside as the lower unit were also identified with the help of negative ion FABMS.Polymeric flavonoids formed between a chalcone and a flavonoid, as yet not identified, are also present in the grain. Key Word Index - Sorghum; Gramineae; flavanoids; glycosides; new oligomer glucosides; procyanidins; chalchone identification.
Flavanone compound as well as preparation method and application thereof
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Paragraph 0202-0205, (2021/04/17)
The invention belongs to the technical field of medicines, and particularly relates to a flavanone compound as well as a preparation method and application thereof. Specifically disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The compound shown in the formula (I) can target hURAT1 and/or GLUT9, so that uric acid excretion is promoted, and the effect of reducing uric acid is achieved. The compound can be used for preparing medicines for treating and/or preventing and/or delaying and/or adjunctively treating and/or treating diseases related to hURAT1/GLUT9 activity, and has a good application prospect in preventing or treating diseases (such as gout, gouty arthritis, uric acid kidney stone and the like) related to hyperuricemia.
Novel chromenone derivatives having substituted biphenyl group and a pharmaceutical composition for prevention or treatment of allergic diseases compring the same
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Paragraph 0157-0164; 0166-0170, (2020/11/26)
The present invention relates to: a novel chromenone derivative compound capable of effectively suppressing an allergic immune response by inhibiting signal transduction mediated by thymic stromal lymphopoietin (TSLP); and a pharmaceutical composition capable of fundamentally preventing or treating various allergic diseases by using the same.COPYRIGHT KIPO 2021