SYNTHESIS OF AMINOCYCLOBUTANE MONO- AND DICARBOXYLIC ACIDS AND DERIVATIVES THEREOF FROM (PHENYLSULFONYL)BICYCLOBUTANES
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Gaoni, Yehiel
p. 185 - 212
(2007/10/02)
Synthesis, NMDA receptor antagonist activity, and anticonvulsant action of 1-aminocyclobutanecarboxylic acid derivatives
A range of cis- and trans-3-substituted 1-aminocyclobutane-1-carboxylic acids has been synthesized and evaluated for antagonism at excitatory amino acid receptor sites and for anticonvulsant activity. Potent and selective antagonist activity at N-methyl-D
Gaoni,Chapman,Parvez,Pook,Jane,Watkins
p. 4288 - 4296
(2007/10/02)
Synthesis and Activity of a Potent N-Methyl-D-aspartic Acid Agonist, trans-1-Aminocyclobutane-1,3-dicarboxylic Acid, and Related Phosphonic and Carboxylic Acids
We report the synthesis of a series of 3-carboxy-, 3-(carboxymethyl)-, 3-(1o-phosphoalkenyl)-, and 3-(1o-phosphonoalkyl)-1-aminocyclobutane-1-carboxylic acids for evaluation as agonists or antagonists of neurotransmission at excitatory amino acid receptor
Allan, Robin D.,Hanrahan, Jane R.,Hambley, Trevor W.,Johnston, Graham A. R.,Mewett, Kenneth N.,Mitrovic, Ann D.
p. 2905 - 2915
(2007/10/02)
Total Synthesis of Cyclobutane Amino Acids from Atelia herbert smithii
The syntheses of two amino acids from the seeds of the legume Atelia herbert smithii, 2,4-methanoproline and 2,4-methanoglutamic acid, are described.The synthesis of third amino acid, cis-1-amino-3-(hydroxymethyl)cyclobutanecarboxylic acid and subsequent
Hughes, Philip,Clardy, Jon
p. 4793 - 4797
(2007/10/02)
REGIOSPECIFIC ADDITIONS OF HYDRAZOIC ACID AND BENZYLAMINE TO 1-(ARYLSULFONYL)BICYCLOBUTANES. APPLICATION TO THE SYNTHESIS OF CIS AND TRANS 2,7-METHANOGLUTAMIC ACIDS
Addition of hydrazoic acid or benzylamine to 1-(arylsulfonyl)bicyclobutanes introduces the nitrogen nucleophile at position 3 of the derived cyclobutane, even when a carboxyl derivative is present at this position as a second activating group.Precursors o
Gaoni, Yehiel
p. 1591 - 1594
(2007/10/02)
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