- Amphiphilic molecule containing o-nitrobenzyl ester photo-degradation group
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The invention discloses a novel photodegradable amphiphilic molecule and a synthetic method thereof, and belongs to the field of surfactants. The synthetic method comprises the five steps that (1) diethylenetriamine pentaacetic acid is taken as a raw material, acetic anhydride is taken as a dehydrating agent, and pyridine catalytic dehydration is performed to produce diethylenetriamine pentaaceticdianhydride; (2) methylene of 6-nitropiperonal is removed under the action of aluminum chloride and hydrobromic acid; (3) 4,5-dihydroxy-2-nitrobenzaldehyde and bromoalkane are subjected to an etherification reaction under an alkaline condition; (4) the 4,5-dihydroxy-2-nitrobenzaldehyde is reduced to 4,5-dihydroxy-2-nitrobenzyl alcohol under the action of a reducing agent; (5) the 4,5-dihydroxy-2-nitrobenzyl alcohol and the excess diethylenetriamine pentaacetic dianhydride are subjected to an esterification reaction to obtain the o-nitrobenzyl ester amphiphilic molecule. The novel photodegradable amphiphilic molecule and the synthetic method thereof have the advantages that the reaction condition of an o-nitrobenzyl alcohol derivative and the diethylenetriamine pentaacetic dianhydride is mild, the excess diethylenetriamine pentaacetic dianhydride is used for reducing the occurrence of side reactions, and the amphiphilic molecule has good ultraviolet photodegradability.
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Paragraph 0038; 0041; 0042
(2019/08/20)
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- Preparation method of near-infrared light-controlled visual medicine carrier
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The invention discloses a near-infrared light-controlled medicine carrier, namely a carrier with medicine carrying ability which is formed by o-nitrobenzyl ester amphiphilic molecule vesicles encapsulating water-soluble upconversion nanoparticles (Ligand-UCNPs), and belongs to the field of surfactants. The total number of alkyl carbon atoms of a fatty chain is 6 to 36. A preparation method of thecarrier comprises the following three steps of synthesizing oil-soluble upconversion nanoparticles (OA-UCNPs); synthesizing the water-soluble upconversion nanoparticles (Ligand-UCNPs); encapsulatingthe upconversion nanoparticles by the o-nitrobenzyl ester amphiphilic molecules. The near-infrared light-controlled medicine carrier has the advantages that the o-nitrobenzyl ester amphiphilic molecules have ultraviolet light crackability; by introducing the upconversion nanoparticles (UCNPs) which have large tissue penetration depth and can convert the near-infrared light with little injury to ahuman body into the ultraviolet light, the defects of small penetration depth and large injury to the human body of the ultraviolet light are overcome, and the purpose of medicine release by photolysis is realized; the near-infrared light-controlled medicine carrier is a potential near-infrared light-controlled medicine release carrier.
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Paragraph 0084-0086
(2019/09/17)
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- Mussel-inspired healing of a strong and stiff polymer
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Self-healability will greatly improve the reliability, service life and maintenance of synthetic materials. However, it remains a big challenge to realize the self-healing of a strong and stiff polymer due to its poor molecular mobility. Inspired by the h
- Chen, Ning,Qin, Liming,Pan, Qinmin
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supporting information
p. 6667 - 6674
(2018/04/23)
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- New fluorine-18 labeled benzaldehydes as precursors in the synthesis of radiopharmaceuticals for positron emission tomography
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4,5-Bis(butoxy)-2-nitrobenzaldehyde and 4,5-bis(tert-butoxycarbonyloxy)-2-nitrobenzaldehyde, as well as their fluorine-18 labeled derivatives (the half-life of F18 is T1/2 = 110 min) were synthesized for use as precursors in the synt
- Orlovskaja,Fedorova,Studentsov,Golovina,Krasikova
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p. 507 - 512
(2017/03/08)
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- An approach to the asymmetric synthesis of 18F-labeled analog of l-threo-3,4-dihydroxyphenylserine (6-l-threo-[18F]FDOPS) - A new radiotracer for visualization of norepinephrine transporters by positron emission tomography
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An asymmetric synthesis method has been suggested as a feasible approach for the preparation of fluorine-18-labeled (T 1/2 110 min) analog of l-threo-3,4-dihydroxyphenylserine, i.e., 6-l-threo-[18F]FDOPS ((2S,3R)-2-amino-3-(2-[1
- Fedorova,Orlovskaya,Maleev,Belokon',Savel'Eva,Chang,Chen,Liu,Krasikova
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p. 1169 - 1177
(2015/04/14)
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- Reaction of caffeic acid derivatives with acidic nitrite
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Caffeic derivatives were reacted with acidic nitrite at controlled pH in order to mimic the gastric juice conditions. At pH 2, whereas caffeic acid reacts exclusively on the side chain, its esters are readily nitrated. Under more acidic conditions (pH 1),
- Cotelle, Philippe,Vezin, Hervé
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p. 3303 - 3305
(2007/10/03)
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- Process for preparing 5,6-dihydroxyindole
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5,6-Dihydroxyindole is prepared by the catalytic reductive cyclization of 4,5-dihydroxy-2,β-dinitrostyrene in a single step using hydrogen with a palladium, platinum or rhodium catalyst in a polar hydroxylic reaction system. No reaction byproducts or only a single reaction byproduct are produced. The 4,5-dihydroxy-2,β-dinitrostyrene intermediate can be prepared by the chemoselective debenzylation of 4,5-dibenzyloxy-2,β-dinitrostyrene using trifluoroacetic acid. 5,6-Dihydroxyindole is a useful component in hair dye formulations and as an intermediate in the synthesis of melanin.
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- SYNTHESIS OF 5,6-DIHYDROXYINDOLE: A NOVEL REDUCTIVE CYCLIZATION OF (E)-4,5-DIHYDROXY-2,β-DINITROSTYRENE
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A unique catalytic reductive cyclization of (E)-4,5-dihydroxy-2,β-dinitrostyrene (1) to 5,6-dihydroxyindole (2) is reported.Compound 1 is obtained either by one-step CF3CO2H deprotection of 4,5-dibenzyloxy-2,β-dinitristyrene (7), or by an improved two-step demethylenation of 6-nitropiperonal (5), followed by condensation with CH3NO2.
- Murphy, Bryan P.,Banks, Harold D.
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p. 321 - 330
(2007/10/02)
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- Synthesis of 6-Aminoisoproterenol
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A number of possible approaches to the ring-aminated isoproterenol derivative 4-ethyl>-5-amino-1,2-benzenediol have been attempted.Of these, the total synthesis using the commercially available starting material 6-nitrop
- Avery, Mitchell A.,Verlander, Michael S.,Goodman, Murray
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p. 2750 - 2753
(2007/10/02)
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