- SYNTHESIS OF 5,6-DIHYDROXYINDOLE: A NOVEL REDUCTIVE CYCLIZATION OF (E)-4,5-DIHYDROXY-2,β-DINITROSTYRENE
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A unique catalytic reductive cyclization of (E)-4,5-dihydroxy-2,β-dinitrostyrene (1) to 5,6-dihydroxyindole (2) is reported.Compound 1 is obtained either by one-step CF3CO2H deprotection of 4,5-dibenzyloxy-2,β-dinitristyrene (7), or by an improved two-step demethylenation of 6-nitropiperonal (5), followed by condensation with CH3NO2.
- Murphy, Bryan P.,Banks, Harold D.
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p. 321 - 330
(2007/10/02)
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