- Syntheses of the antibiotic alkaloids renierone, mimocin, renierol, renierol acetate, renierol propionate, and 7-methoxy-1,6-dimethylisoquinoline-5, 8-dione
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The total synthesis of renierone, mimocin, renierol, renierol acetate, renierol propionate, and 7-methoxy-1,6-dimethylisoquinoline-5,8-dione was successfully achieved by the regioselective oxidation of 5-oxygenated isoquinoline. The synthetic method of the 5-oxygenated isoquinoline is based on the thermal electrocyclic reaction of 1-azahexatriene system involving the benzene 1,2-bond.
- Kuwabara, Nagako,Hayashi, Hiroyuki,Hiramatsu, Noriko,Choshi, Tominari,Kumemura, Teppei,Nobuhiro, Junko,Hibino, Satoshi
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p. 2943 - 2952
(2007/10/03)
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- Chemistry of renieramycins. Part 6: Transformation of renieramycin M into jorumycin and renieramycin J including oxidative degradation products, mimosamycin, renierone, and renierol acetate
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The transformation of renieramycin M (1m) into renieramycin J (1j) and jorumycin (2) is presented along with the results of antiproliferative assay data. The chemical stability and the oxidative degradation of 2 and renieramycin E (1e) to generate simple isoquinoline alkaloids, such as mimosamycin (7), renierol acetate (12), and renierone (8) are also described.
- Saito, Naoki,Tanaka, Chieko,Koizumi, Yu-Ichi,Suwanborirux, Khanit,Amnuoypol, Surattana,Pummangura, Sunibhond,Kubo, Akinori
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p. 3873 - 3881
(2007/10/03)
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