- Preparation method of ethylene sulfite
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The preparation method comprises the following steps 1) adding ethylene glycol disodium salt into a solvent, adding thionyl chloride dropwise to a certain temperature under the protection of nitrogen, adding the sodium bicarbonate aqueous solution to neutrality after a period of time, and separating the organic phase. 2) The organic phase was dried over anhydrous sodium sulfate, the solvent was recovered at atmospheric pressure, and vinyl sulfite was obtained under reduced pressure. 1) The synthetic method disclosed by the invention has the following beneficial effects that the ethylene glycol disodium salt is taken as a raw material and reacted with thionyl chloride in a solvent to synthesize ethylene sulfite. , The production cost is reduced, and great economic benefits and social benefits are achieved.
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Paragraph 0019
(2021/10/27)
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- TEREPHTHALIC ACID ESTERS FORMATION
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The present disclosure relates to the formation of dimethyl terephthalate (DMT). The present invention also relates to the depolymerization of polyethylene terephthalate (PET) and the recovery of dimethyl terephthalate (DMT).
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Paragraph 0232
(2020/01/12)
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- Synthesis of Functionalized 1,4-Dioxanes with an Additional (Hetero)Aliphatic Ring
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An approach to the preparation of 2-mono-, 2,2- and 2,3-disubstituted 1,4-dioxane derivatives is described. The reaction sequence commences from readily available epoxides, in most cases prepared via the Corey-Chaikovsky reaction of the corresponding aldehydes and ketones. The key step of the method is epoxide ring opening with ethylene glycol monosodium salt, followed by further cyclization of the diols obtained. The utility of the approach was demonstrated by multigram preparation of novel functionalized 1,4-dioxanes bearing additional cycloalkane, piperidine or pyrrolidine rings, mostly spirocyclic compounds, which are advanced building blocks for medicinal chemistry.
- Bondarenko, Andriy V.,Tolmachev, Andrey A.,Vashchenko, Bohdan V.,Grygorenko, Oleksandr O.
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p. 3696 - 3707
(2018/09/14)
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- Synthesis and biological evaluation of a series of N-alkylated imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors
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In this paper, we report the synthesis and biological evaluation of a series of 1,5- and 1,4- substituted derivatives of 1H-imidazol-4-ylacetic acid, a series of 1,2-substituted 3-(1H-imidazol-2-yl)propanoic acid and an N-substituted (2E)-3-(1H-imidazol-2-yl)prop-2-enoic acid as new mGAT3 inhibitors. The lipophilic moieties attached to the N-atom of the parent structures were delineated from the 2-[9-(4-methoxyphenyl)-9H-fluoren-9-yl]oxyethyl residue, known from a prototypic mGAT3 inhibitor. For the structure-activity-relationship studies, the spacer between the N-atom of the imidazole ring and the 2-[9-(4-methoxyphenyl)-9H-fluoren-9-yl] moiety was varied in length from three to six atoms, and in nature being either a pure saturated or unsaturated alkyl chain or an alkyl chain containing up to two ether functions. The compounds were characterized for inhibitory potencies at mouse GABA transporter proteins mGAT1–mGAT4. Among the 1,2-substituted compounds, the N-alkylated (2E)-3-(1H-imidazol-2-yl)prop-2-enoic acid 12e containing a C5O spacer exhibits a pIC50value of 5.13?±?0.04 at mGAT3, but is devoid of significant selectivity for this GABA transporter. However, the inhibitory potency displayed by 12e at mGAT3 nominally surpasses that of SNAP-5294 reported as the most potent inhibitor of mGAT3 so far.
- Kerscher-Hack, Silke,Renukappa-Gutke, Thejavathi,H?fner, Georg,Wanner, Klaus T.
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p. 852 - 880
(2016/09/23)
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- Solubility of potassium and sodium orthophosphates in ethylene glycol
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Solubility of potassium and sodium orthophosphates in ethylene glycol was determined.
- Kurzin,Evdokimov,Golikova,Fedorov
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p. 841 - 842
(2012/07/17)
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- CHEMICAL COMPOUNDS
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Quinazoline derivatives of formula (I); for use in the treatment of proliferative diseases such as cancer and in the preparation of medicaments for use in the treatment of proliferative diseases, and to processes for their preparation, as well as pharmaceutical compositions containing them as active ingredient.
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- NOVEL HERBICIDES
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Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I are suitable for use as herbicides.
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- Process for producing a fluorine atom-containing sulfonyl fluoride compound
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The present invention provides a process whereby fluorine atom-containing sulfonyl fluoride compound(s) useful as e.g. materials for ion-exchange membranes, can be produced efficiently and at low cost without structural limitations while solving the difficulties in production. Namely, the present invention provides a process which comprises reacting XSO2RA-E1 (1) with RB-E2 (2) to form XSO2RA-E—RB (3), then reacting (3) with fluorine in a liquid phase to form FSO2RAF-EF-RBF (4), and further, decomposing the compound to obtain FSO2RAF-EF1 (5), wherein RA is a bivalent organic group, E1 is a monovalent reactive group, RB is a monovalent organic group, E2 is a monovalent reactive group which is reactive with E1, E is a bivalent connecting group formed by the reaction of E1 with E2, RAF is a bivalent organic group formed by the fluorination of RA, etc., RBF is the same group as RB, etc., EF is a bivalent connecting group formed by the fluorination of E, etc., EF1 is a monovalent group formed by the decomposition of EF, and X is a halogen atom.
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Page/Page column 10-11
(2008/06/13)
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- Purified salt of beta-hydroxyethoxy acetic acid, purified 2-p-dioxanone, and manufacturing method therefor
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A purified salt of β-hydroxyethoxy acetic acid of formula (1) having a fusion peak-top temperature detected by differential scanning calorimetry (DSC) and a purified 2-p-dioxanone of formula (2) derived from the purified salt of β-hydroxyethoxy acetic acid of formula (1). (wherein in formula (1), n=1-2 , and if n=1, M is Na and/or K, and, if n=2, M is Ca and/or Mg.)
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- Stereochemical Studies on Hemiorthothiol and Hemiorthothiolate Tetrahedral Intermediates
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This study deals with hemiorthothiol-RC(OR')2SH-tetrahedral intermediates including (a) two acyclic ones of type , (b) two types of monocyclics and , and (c) four bicyclic systems , , , and .The breakdown of (R = Ph, R' = Et) led to thiono esters 34 and 35; that of (R = Me, Ph) resulted in hydroxy thiono esters 36-39, whereas the cleavage of (R =Me, Et) yielded thionolactones 49-53 and hydroxy thiono esters 55-58.The study of rigid bicyclic intermediates - helped uncover the role of stereoelectronic effects in the breakdown of hemiorthothiol tetrahedral intermediates.Finally, a family of isolable hemiorthothiolate tetrahedral intermediates-RC(OR')2S-+Na-viz. ->--> (monocyclic) and -> (bicyclic) is reported.
- Khouri, Farid F.,Kaloustian, Moses K.
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p. 6683 - 6695
(2007/10/02)
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- Synthesis of (R,S)-(5Z,8E,10E)-12-Hydroxyheptadeca-5,8,10-trienoic Acid and of (R,S) and (S)-(5Z,8Z,10E,14Z)-12-Hydroxyeicosa-5,8,10,14-tetraenoic Acid and their Racemic 5,6,8,9-tetradeuterioisomers
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(5Z,8Z,10E,14E)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid , (R,S)-(5Z,8Z,10E,14Z)-12-hydroxy-5,6,8,9-tetradeuterio-5,8,10,14-tetraenoic acid, (R,S)-(5Z,8E,10E)-12-hydroxyheptadeca-5,8,10-trienoic acid, and (R,S)-(5Z,8E,10E)-12-hydroxy-5,6,8,9-tetradeuterioheptadeca-5,8,10-trienoic acid have been prepared by total synthesis.Deuterium was introduced at selected sites by partial reduction.All the acids were prepared from the common intermediate ethyl 10,10-diethoxydeca-5,8-dienoate.The c.d. spectrum of (S)-(7h) confirmed its identity with the natural product.The mechanism of the reaction of heptynyl-lithium with (S)-1-chloro-2,3-epoxypropane has been shown to be by attack on the epoxide group, with subsequent recyclisation of the chloroalkoxide to give (S)-1,2-epoxydec-4-yne.
- Russel, Stephen W.,Pabon, Henk J. J.
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p. 545 - 552
(2007/10/02)
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- Chemical detoxification of toxic chlorinated aromatic compounds
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A method for the reduction of the content of toxic chlorinated aromatic compounds such as chlorinated aromatic dioxins and especially chlorinated dibenzo-p-dioxins in reaction products to virtually zero consisting essentially of reacting a mass containing chlorinated aromatic dioxins with an amount, in excess of stoichiometrical based on the total organic halogen content, of alkaline reactants selected from the group consisting of (1) alkali metal alcoholates of alcohols selected from the group consisting of alkanols having from 1 to 5 carbon atoms, polyalkoxyalkane glycols having 4 to 20 carbon atoms, alkanepolyols having from 2 to 5 carbon atoms and 2 to 3 hydroxyls, and monoalkyl ethers of such alkanepolyols with alkanols having from 1 to 4 carbon atoms, or (2) mixtures of said alcohols with alkaline reactants selected from the group consisting of alkali metal hydroxides and carbonates, at a reaction temperature of from 140° C. to 220° C. for a time sufficient to convert the organic halogen into inorganic halide, recovering a reaction mass essentially free of chlorinated aromatic dioxins, and optionally suspending said recovered reaction mass in water and extracting with an organic solvent to remove any minute residual chlorinated aromatic dioxins, and recycling said solvent extract to said reacting step.
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