74124-11-1Relevant articles and documents
Regioselective Deacylation of 2,4-Diacylaminopyrimidine Derivatives by Lewis Acids and Crystal Structures of Two Products
Griffin, Roger J.,Lowe, Philip R.
, p. 1811 - 1820 (2007/10/02)
Deacylation of 2,4-diacylamino derivatives of pyrimethamine and related diaminopyrimidines with tin(II) chloride or zinc chloride, in ethanol or propan-2-ol, affords 2-acyl-4-aminopyrimidines exclusively.Regioselective 4-deacylation was observed by 1H NMR spectroscopy and established by crystallographic analysis of the 2,4-dipropionylpyrimidine 11 and the corresponding 4-amino-2-propionylpyrimidine deacylation product 17.The latter exists in the solid state as an unusual base-pair dimer linked by two pairs of equivalent hydrogen bonds.
CHARACTERIZATION AND ANTIMALARIAL ACTIVITY OF FOUR ACETYLATED PYRIMETHAMINES
Acton, Nancy,Brossi, Arnold,Davidson, David E.,Sweeney, Thomas R.
, p. 471 - 476 (2007/10/02)
Acetylation of the antimalarial drug pyrimethamine afforded four different N-acetyl derivatives which were characterized.These derivatives do not show sustained release activity but they are active antimalarials per se.